Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
| Autor: | Thomas-Thi Pluess, Burkhard Michaeli, Daniel Hayoz, Yvon Carpentier, Luc Tappy, René Chioléro, Jean-Pierre Revelly, Mette M. Berger |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Lipopolysaccharides Male Fat Emulsions Intravenous medicine.medical_specialty Resuscitation Lipopolysaccharide medicine.medical_treatment Phospholipid Critical Care and Intensive Care Medicine Omegaven chemistry.chemical_compound Fish Oils Heart Rate Intensive care Internal medicine Humans Medicine Platelet Inflammation business.industry Baroreflex Fish oil Endotoxins Cytokine Endocrinology chemistry Immunology business Adult Baroreflex/*drug effects Endotoxins/*adverse effects/antagonists & inhibitors *Fat Emulsions Intravenous/pharmacology Fish Oils/administration & dosage/*pharmacology Heart Rate/drug effects Humans Inflammation/blood/prevention & control/*therapy *Lipopolysaccharides Male |
| Zdroj: | Intensive Care Medicine, vol. 33, no. 5, pp. 789-97 |
| Popis: | OBJECTIVE: To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN: Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24h before investigation. LPS (2 ng/kg) was injected as a bolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured. RESULTS: Basal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the control [corrected] group than in FO group [corrected] the difference was significant from t (120) until t (360). FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t (120) while the ACTH peak was fourfold lower. Tumor necrosis factor alpha was significantly lower between t (360) and t (180) in the FO group. CONCLUSIONS: Two doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|