Inhibition of DOI-induced wet dog shakes in the guinea-pig by 5-HT2 receptor antagonists
| Autor: | M. Skingle, Guy A. Higgins, W. Feniuk, Nicola Cole |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Agonist Spiperone medicine.medical_specialty Ketanserin medicine.drug_class 5-HT2 receptor Biology Receptor antagonist humanities 030227 psychiatry Guinea pig 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Endocrinology Internal medicine medicine Pharmacology (medical) Antagonism Receptor 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of psychopharmacology (Oxford, England). 5(3) |
| ISSN: | 0269-8811 |
| Popis: | The preferential 5-HT 2/5-HT1C receptor agonist DOI (0.1-4 mg/kg s.c.) caused an increase in locomotor activity, grooming and 'wet-dog' shakes (WDS) in the adult guinea-pig. The DOI-induced WDS behaviour was potently inhibited by several antagonists that have high affinity for the 5-HT2 binding site. The WDS response is likely to be centrally-mediated since the effects of peripherally administered DOI were poorly antagonized by the peripherally-acting 5-HT2 receptor antagonist BW501C67. Although these studies do not exclude an effect of DOI at 5-HT1C receptors, the high potency of ketanserin and spiperone in attenuating the effects of DOI would suggest an effect at the 5-HT2 receptor. The present data suggest that antagonism of the directly-acting agonist DOI may be useful for assessing the selectivity and duration of action of centrally-acting 5-HT2 receptor antagonists in the guinea-pig. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|