Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits

Autor: Nadine Marecaux, Julie Dumont, Louisa Goumidi, Benjamin Grenier-Boley, Jean Dallongeville, Michèle Montaye, Dominique Arveiler, Dominique Cottel, Jean Ferrières, Philippe Amouyel, Aline Wagner, Jean-Bernard Ruidavets, Chantal Simon, Aline Meirhaeghe
Přispěvatelé: Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, The MONA LISA study was supported by a grant from the Agence Nationale de la Recherche [ANR-05-PNRA-018], the Institut National de Veille Sanitaire, INSERM, and a grant from Pfizer. This work was funded by the European Regional Development Fund and the Conseil Régional du Nord-Pas de Calais as part of the CPER Cardio-diabete program [contract 09220016]., ANR-05-PNRA-0018,MONA LISA-NUT,MONA LISA – NUT (MOnitoring NAtionaL du rISque Artériel – NUTrition). Relations entre les habitudes alimentaires et la prévalence des facteurs de risque cardiovasculaire dans trois régions françaises.(2005), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement (Inserm U1167 - RID-AGE - Institut Pasteur), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), ANR-05-PNRA-0018,MONA LISA-NUT,MONA LISA – NUT (MOnitoring NAtionaL du rISque Artériel – NUTrition). Relations entre les habitudes alimentaires et la prévalence des facteurs de risque cardiovasculaireans trois régions françaises.(2005), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Fatty Acid Desaturases
0301 basic medicine
Linoleic acid
obesity
variabilité génétique
Critical Care and Intensive Care Medicine
Body Mass Index
chemistry.chemical_compound
Delta-5 Fatty Acid Desaturase
Gene Frequency
genetic variability
Medicine
2. Zero hunger
chemistry.chemical_classification
education.field_of_study
Nutrition and Dietetics
acide gras
alpha-Linolenic Acid
cholestérol
Middle Aged
Lipid
Lipids
obésité
régime alimentaire
lipids (amino acids
peptides
and proteins)
France
Waist Circumference
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
FADS1 gene
Waist
FADS1
FADS2
Population
Polymorphism
Single Nucleotide
03 medical and health sciences
Internal medicine
Humans
education
business.industry
Cholesterol
Cholesterol
HDL
acide linoléique
Diet
030104 developmental biology
Endocrinology
chemistry
fatty acid
business
Body mass index
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Clinical Nutrition
Clinical Nutrition, Elsevier, 2018, 37 (5), pp.1683-1689. ⟨10.1016/j.clnu.2017.07.012⟩
Clinical Nutrition, 2018, 37 (5), pp.1683-1689. ⟨10.1016/j.clnu.2017.07.012⟩
ISSN: 0261-5614
1532-1983
Popis: Background & aims: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Delta 5- and Delta 6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet. Genome-wide associations studies (GWAS) reported associations between polymorphisms in FADS1-FADS2 and variations in plasma concentrations of PUFAs, HDL- and LDL-cholesterol and triglycerides. However, it is not established whether dietary PUFAs intake modulates these associations. We assessed whether dietary linoleic acid (LA) or alpha-linolenic acid (ALA) modulate the association between the FADS1 rs174547 polymorphism (a GWAS hit) and lipid and anthropometric phenotypes. Methods: Dietary intakes of LA and ALA, FADS1 rs174547 genotypes, lipid and anthropometric variables were determined in three French population-based samples (n = 3069). These samples were stratified according to the median dietary LA (= 9.5 g/d) and ALA (= 0.80 g/d) intakes. The meta-analysis was performed using a random-effect. Results: Our meta-analysis confirmed the association between rs174547 and plasma lipid levels and revealed an association with waist circumference and body mass index. These associations were not modified by dietary ALA intake (all p-interaction > 0.05). In contrast, the associations with HDL-cholesterol levels, waist circumference and BMI were modulated by the dietary intake of LA (p interaction < 0.05). In high LA consumers only, the rs174547 minor allele was significantly associated with lower HDL-cholesterol levels (beta = -0.05 mmol/L, p = 0.0002). Furthermore, each copy of the rs174547 minor allele was associated with a 1.58 cm lower waist circumference (p = 0.0005) and a 0.46 kg M-2 lower BMI (p = 0.01) in the low LA intake group, but not in the high LA intake group. Conclusions: The present study suggests that dietary LA intake may modulate the association between the FADS gene variants and HDL-cholesterol concentration, waist circumference and BMI. These gene -nutrient interactions, if confirmed, suggest that subjects carrying the rs174547 minor allele might benefit from low dietary LA intakes. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Databáze: OpenAIRE
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