Isoindole Derivatives: Propitious Anticancer Structural Motifs
| Autor: | Richa Kaur Bhatia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Molecular Structure
010405 organic chemistry Chemistry Rational design Antineoplastic Agents Biological activity General Medicine Isoindoles 010402 general chemistry Antimicrobial 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Drug Discovery Humans Structural motif Isoindole |
| Zdroj: | Current Topics in Medicinal Chemistry. 17:189-207 |
| ISSN: | 1568-0266 |
| DOI: | 10.2174/1568026616666160530154100 |
| Popis: | Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin inhibition with special emphasis on anticancer activity. This review highlights anticancer properties of isoindole derivatives and its related structures and hoping that it would further help in generation of new concepts towards rational design and development of more potent and less toxic anticancer agents. |
| Databáze: | OpenAIRE |
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