Differential cytokine levels in adults induced by a Novel candidate TB boost vaccine, MVA85A-according to previous BCG vaccination status

Autor:	Roger H. Brookes, Hannah B. Ibanga, Helen McShane, Martin O. C. Ota, Philip C. Hill, Jayne S. Sutherl, Patrick K. Owiafe
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Tuberculosis Cytokine Therapy business.industry medicine.medical_treatment Immunology medicine.disease complex mixtures Virology Vaccination Pathogenesis Cytokine release syndrome Immune system Cytokine Drug Discovery medicine Immunology and Allergy business Cytokine storm
Popis:	MVA85A is a candidate boost vaccine for TB. A previously reported study showed no differences in response to MVA85A in 10 BCG vaccinated (BCG+) and 11 BCG naive (BCG-) adult Gambians. Here we evaluated the effect of pre-existing plasma cytokines in both groups before and after MVA85A vaccination on the vaccine-induced immune response. Pre-vaccination levels of IL-8 were higher in BCG+ subjects, whilst MCP-1 levels were lower compared to BCG-. Following MVA85A vaccination, concentrations of IL-8, IL-18, IL-12(p70) and MCP-1 were differentially induced between BCG+ and BCG- groups. The implications of these findings depend on their role in TB pathogenesis. © 2012 Owiafe PK, et al.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4236f182abc1de303d5a2d45b87cab1 https://doi.org/10.4172/2157-7560.1000158 Zobrazit plný text záznamu