Autologous cytolytic T lymphocytes recognize a MAGE-1 nonapeptide on melanomas expressing HLA-Cw* 1601
| Autor: | Jean-Pierre Szikora, Michel Somville, Pascale Boel, Thierry Boon, Claude Wildmann, Marialuisa Sensi, Pierre van der Bruggen |
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| Rok vydání: | 1994 |
| Předmět: |
endocrine system
Receptors Antigen T-Cell alpha-beta Molecular Sequence Data Immunology HLA-C Antigens Human leukocyte antigen Biology Transfection Epitopes Antigen Antigens Neoplasm Humans Immunology and Allergy Amino Acid Sequence Melanoma neoplasms Gene Genomic Library Base Sequence Tumor Necrosis Factor-alpha T lymphocyte Tumor antigen Neoplasm Proteins CTL Cytolysis Exodeoxyribonucleases Cell culture Peptides Melanoma-Specific Antigens T-Lymphocytes Cytotoxic |
| Zdroj: | European Journal of Immunology. 24:2134-2140 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830240930 |
| Popis: | Human melanoma cell line MZ2-MEL expresses several antigens recognized by autologous cytolytic T lymphocyte (CTL) clones. We reported previously the identification of a gene, named MAGE-1, which codes for antigen MZ2-E which is presented by HLA-A1. Gene MAGE-1 is expressed in many tumors of several types but not in normal tissues except for testis. We show here that gene MAGE-1 directs the expression of another antigen recognized by CTL on the MZ2-MEL cells. This antigen, which was named MZ2-Bb, consists of MAGE-1-encoded peptide SAYGEPRKL bound to major histocompatibility molecule HLA-Cw*1601. The HLA-Cw*1601 allele was found to be expressed by 7 out of 99 individuals from a Caucasian population. Our results extend the range of tumor patients who could be eligible for immunization against MAGE antigens. |
| Databáze: | OpenAIRE |
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