Number and percentage of NK-cells are decreased in growth hormone-deficient adults
| Autor: | G. F. F. M. Pieters, Peter W. C. Kloppenborg, P.P. Koopmans, J. P. T. Span, A. G. H. Smals |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cellular immunity medicine.medical_specialty Adolescent Lymphocyte CD3 Immunology Biology Pathology and Forensic Medicine Natural killer cell Growth hormone deficiency Immune system Immunopathology Internal medicine Lymphopenia medicine Immunology and Allergy Humans Lymphocyte Count GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Diagnosis and therapy of growth hormone deficiency and excess in adults Aged Immunity Cellular Diagnostiek en therapie van groeihormoon-deficientie en -exces bij volwassenen Middle Aged medicine.disease Killer Cells Natural medicine.anatomical_structure Endocrinology Growth Hormone biology.protein Female CD8 |
| Zdroj: | Clinical Immunology and Immunopathology, 78, 90-92 Clinical Immunology and Immunopathology, 78, pp. 90-92 Clinical Immunology and Immunopathology, 78, 1, pp. 90-92 |
| ISSN: | 0090-1229 |
| Popis: | Snell-Bagg mice and Ames dwarf mice repeatedly show severe immunodeficiencies, affecting mostly the thymus-dependent lymphocyte system, probably caused by growth hormone deficiency. In growth hormone-deficient children contradictory data on the immune status have been reported. We investigated indices of cellular immunity in 22 adult patients with proven growth hormone deficiency in comparison to those in 100 healthy volunteers. Cellular immunity was assessed using total leukocyte count, percentage lymphocytes, and percentage and absolute numbers of CD3, CD4, CD8, CD19, and CD3−CD56+(NK)-cells. Comparison revealed statistically significant lower percentage and absolute number of NK-cells (P< 0.001). Except for a trend toward an increased CD4/CD8 ratio, no statistically significant differences for B- and T-lymphocytes could be obsereved. No correlation between the percentage and absolute number of NK-cells, on one hand, and the duration of growth hormone deficiency or prolactin level, on the other hand, could be demonstrated. In all these respects men did not differ from women. So, in growth hormone-deficienct adults the percentage and absolute number of NK-cells are decreased. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect