Portable neuromodulation induces neuroplasticity to re-activate motor function recovery from brain injury: a high-density MEG case study

Autor: Pamela Tannouri, Pauline Martin, Fabio Bollinger, Debbie Greene, Natasha K J Campbell, Zack Frehlick, Yuri Danilov, Shaun D. Fickling, Ashley C. Livingstone, Ryan C.N. D'Arcy, Christopher J. Smith, Bimal Lakhani, Tori Etheridge, Trevor Greene
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
Canada
030506 rehabilitation
Traumatic brain injury
medicine.medical_treatment
Electric Stimulation Therapy
Health Informatics
Electroencephalography
behavioral disciplines and activities
Translingual neurostimulation (TLNS)
lcsh:RC321-571
Functional connectivity
03 medical and health sciences
0302 clinical medicine
Brain Injuries
Traumatic
Neuroplasticity
Humans
Medicine
Magnetoencephalography (MEG)
Electroencephalography (EEG)
Traumatic brain injury (TBI)
Neurostimulation
Motor function
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Physical Therapy Modalities
Neuronal Plasticity
Rehabilitation
medicine.diagnostic_test
Brain vital signs
business.industry
Research
Brain
Magnetoencephalography
Recovery of Function
medicine.disease
Magnetic Resonance Imaging
Neuromodulation (medicine)
Functional imaging
Portable neuromodulation stimulator (PoNS)
nervous system
0305 other medical science
business
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Zdroj: Journal of NeuroEngineering and Rehabilitation, Vol 17, Iss 1, Pp 1-12 (2020)
Journal of NeuroEngineering and Rehabilitation
ISSN: 1743-0003
Popis: Background In a recent high-profile case study, we used functional magnetic resonance imaging (fMRI) to monitor improvements in motor function related to neuroplasticity following rehabilitation for severe traumatic brain injury (TBI). The findings demonstrated that motor function improvements can occur years beyond current established limits. The current study extends the functional imaging investigation to characterize neuromodulation effects on neuroplasticity to further push the limits. Methods Canadian Soldier Captain (retired) Trevor Greene (TG) survived a severe open-TBI when attacked with an axe during a 2006 combat tour in Afghanistan. TG has since continued intensive daily rehabilitation to recover motor function, experiencing an extended plateau using conventional physical therapy. To overcome this plateau, we paired translingual neurostimulation (TLNS) with the continuing rehabilitation program. Results Combining TLNS with rehabilitation resulted in demonstrable clinical improvements along with corresponding changes in movement evoked electro-encephalography (EEG) activity. High-density magneto-encephalography (MEG) characterized cortical activation changes in corresponding beta frequency range (27 Hz). MEG activation changes corresponded with reduced interhemispheric inhibition in the post-central gyri regions together with increased right superior/middle frontal activation suggesting large scale network level changes. Conclusions The findings provide valuable insight into the potential importance of non-invasive neuromodulation to enhance neuroplasticity mechanisms for recovery beyond the perceived limits of rehabilitation.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje