Post-Burn Pruritus
| Autor: | Bo Young Chung, Chun Wook Park, Han Bi Kim, Seok Young Kang, Min Je Jung, In-Suk Kwak, Hye One Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Keratinocytes
Burn injury neuroleptic agent substance P Narcotic Antagonists Pregabalin Review sensitization lcsh:Chemistry 030207 dermatology & venereal diseases GABA 0302 clinical medicine Medicine burn skin and connective tissue diseases lcsh:QH301-705.5 Spectroscopy Sensitization integumentary system General Medicine Ondansetron Computer Science Applications medicine.anatomical_structure Nociceptor medicine.symptom Gabapentin Burns medicine.drug Antipsychotic Agents medicine.medical_specialty Histamine Antagonists Connective tissue Catalysis Inorganic Chemistry 03 medical and health sciences Animals Humans Physical and Theoretical Chemistry Molecular Biology Inflammation Wound Healing antidepressant business.industry Pruritus Organic Chemistry Neuropeptides 030208 emergency & critical care medicine Dermatology opioid antagonist lcsh:Biology (General) lcsh:QD1-999 TRPV Receptors Opioid Itching neuropathy business Wound healing |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 3880, p 3880 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Many potential treatments are available for pruritus but there is no consensus of the best single treatment yet. The precise mechanism of post-burn pruritus has not been elucidated, but it appears to have pruritogenic and neuropathic aspects. Clinically, post-burn pruritus tends to be intractable to conventional treatment but rather responds to neuroleptic agents, such as gabapentin and pregabalin. During wound healing, various neuropeptides secreted from the nerves of the skin control epidermal and vascular proliferation and connective tissue cells. When keratinocytes are activated by an itch-inducing substance, they secrete a variety of inflammatory substances that increase the susceptibility of the itch receptor. There are two mechanisms underlying post-burn neuropathic pruritus. The first one is peripheral sensitization. The second one is the intact nociceptor hypothesis. An effective treatment for post-burn pruritus will also be effective in other neuropathic and intractable itching. In this review, we summarized the interaction and mechanism of keratinocytes, immune cells, and nerve fibers related to post-burn pruritus. |
| Databáze: | OpenAIRE |
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