In Vivo Activities and In Silico Study of Jackfruit Seeds (Artocarpus heterophyllus Lam.) on the Reduction of Blood Sugar Levels of Gestational Diabetes Rate Induced by Streptozotocin
| Autor: | Kriana Efendi, Rizky Arcinthya Rachmania, Pahlevi Jihadudin, Riri Septiani, Dwitiyanti Dwitiyanti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medicine
Blood sugar 030209 endocrinology & metabolism Pharmacology streptozotocin Herbal Medicine in Pharmaceutical and Clinical Sciences Glibenclamide 03 medical and health sciences Artocarpus chemistry.chemical_compound 0302 clinical medicine In vivo medicine 030212 general & internal medicine Ethanol Artocarpus heterophyllus biology business.industry lcsh:R General Medicine medicine.disease biology.organism_classification Streptozotocin Gestational diabetes in vivo chemistry in silico Sulfonylurea receptor gestational diabetes business medicine.drug |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences; Vol. 7 No. 22 (2019): Nov 30 (Herbal Medicine in Pharmaceutical and Clinical Sciences); 3819-3826 Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences, Vol 7, Iss 22 (2019) |
| ISSN: | 1857-9655 |
| Popis: | BACKGROUND: Jackfruit Seeds (Artocarpus heterophyllus L.) are plants that are thought to be able to reduce blood sugar levels. AIM: The purpose of this study was to prove the activity of jackfruit seeds in reducing blood glucose levels in gestational diabetic rats induced by streptozotocin and in silico study virtual screening through molecular docking to find out the compounds in jackfruit seeds that have interaction with sulfonylurea receptors. METHODS: The animals used in this study were Sprague Dawley strain pregnant female rats which were divided into six groups, namely the normal control group, negative control, positive control, various dose groups (100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW). After the rat was pregnant, the rats were induced first with streptozotocin so that the rats had hyperglycemia. Blood glucose levels were measured on the 14th day after treatment. The data obtained were statistically tested by one-way ANOVA test followed by the HSD Tukey test. Virtual screening was done using PLANTS 1.2 software. RESULTS: The results showed that all groups of ethanol extract 70% of jackfruit seeds could reduce blood glucose levels. The biggest decrease in blood glucose levels occurred at dose 3 with a dose of 400 mg/kg BW which was 61.73%, comparable to positive control glibenclamide. The results of virtual screening with molecular docking showed that betacarotene epoxide compounds have better affinity than glibenclamide as a comparative compound. CONCLUSION: It can be concluded that jackfruit seeds beta-carotene epoxide has the potential to reduce blood sugar levels by inducing insulin secretion. |
| Databáze: | OpenAIRE |
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