Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics
| Autor: | Sergio Pina-Oviedo, Brian J. Augelli, S. Ausim Azizi, Kamel Khalili, Barbara Krynska, Georgina Perez-Liz, Luis Del Valle, Jennifer Gordon |
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| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Mice Nude Neuroectodermal Tumors Biology Article Mice Cancer stem cell medicine Animals Humans Antigens Viral Tumor Stem cell transplantation for articular cartilage repair Pharmacology Mesenchymal stem cell Amniotic stem cells Mesenchymal Stem Cells JC Virus Rats Endothelial stem cell Adult Stem Cells medicine.anatomical_structure Cell Transformation Neoplastic Oncology Cancer research Molecular Medicine Bone marrow Stem cell Neoplasm Transplantation Adult stem cell |
| Zdroj: | Cancer biologytherapy. 9(4) |
| ISSN: | 1555-8576 |
| Popis: | There is now accumulating evidence showing that some tumors may arise from transformed stem cells. In this study we demonstrate that adult bone marrow- derived mesenchymal stem cells (MSCs) undergo neoplastic transformation induced by the human polyomavirus JCV, early protein, T-antigen, and are tumorigenic when transplanted into the flanks of Nude mice as compared to non-transformed MSCs. Histologically, the tumors are heterogeneous with mesenchymal and neural crest characteristics as evidenced by expression of the neural crest markers p75, SOX-10, and S-100, with populations of tumor cells exhibiting characteristics of primitive neuroectodermal cells. In addition, a subset of T-antigen positive tumor cells exhibit a high proliferation index as detected by Ki-67 labeling, and co-express CD133, a marker which is expressed on cancer stem cells. These results show that tumors with neuroectodermal characteristics may arise from transformation of MSCs, a globally accessible adult stem cell with multipotent differentiation capacity. In light of earlier reports on the association of JCV with a broad variety of human tumors, our data suggests that T-antigen transformation of adult stem cells with a multipotent capacity can serve as a possible common origin for some of these cancers, and offers a novel model for oncogenesis. |
| Databáze: | OpenAIRE |
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