The association between serum adiponectin and 3-month outcome after ischemic stroke

Autor: Shuo Wang, Bo Li, Yong-xin Wang, Aisha Maimaitili, Geng Dangmurenjiafu, Zengliang Wang, Hu Qin
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology
Diabetes and Metabolism
Adipokine
030209 endocrinology & metabolism
Enzyme-Linked Immunosorbent Assay
030204 cardiovascular system & hematology
Logistic regression
Risk Assessment
Brain Ischemia
03 medical and health sciences
Disability Evaluation
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Humans
Clinical significance
Prospective Studies
Stroke
Aged
Original Investigation
Aged
80 and over
Ischemic stroke
Adiponectin
business.industry
Odds ratio
Recovery of Function
Middle Aged
Functional outcome
medicine.disease
Up-Regulation
Treatment Outcome
lcsh:RC666-701
Case-Control Studies
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Cohort study
Zdroj: Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-10 (2019)
Cardiovascular Diabetology
ISSN: 1475-2840
DOI: 10.1186/s12933-019-0908-z
Popis: Background Although adiponectin is a major adipocytokine that affects the pathogenesis of various cardiovascular diseases, its clinical significance in stroke remains controversial. The purpose of this study was to assess the impact of serum adiponectin levels on functional prognosis in patients with ischemic stroke. Methods This was a prospective, observational cohort study. Consecutive first-ever ischemic stroke patients without any pre-morbid handicap admitted to our hospital were identified from December 2017 to December 2018. Serum concentration of adiponectin was routinely measured within the first 24 h after admission by a commercially available sandwich ELISA. Associations between adiponectin and either clinical severity at admission, poor outcomes or mortality at 3-month after admission were analyzed using logistic regression to obtain odds ratios (OR) and 95% confidence intervals (CI). Results The serum level of adiponectin was obtained in 227 patients with a median value of 7.0 μg/ml, which was significantly higher (P P = 0.002). Patients with a poor outcome and nonsurvivors had significantly increased adiponectin levels on admission (P P P P Conclusions Our results show that high adiponectin is associated with stroke severity and support the hypothesis that adiponectin can be serve as a biomarker of poor outcome after stroke, independent of baseline variables. Trial registration ChiCTR-OPC-17013501. Retrospectively Registered 21 September 2017
Databáze: OpenAIRE
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