Personalized Embryo Transfer Helps in Improving In vitro Fertilization/ICSI Outcomes in Patients with Recurrent Implantation Failure
| Autor: | Jwal Banker, Sandeep Shah, Jayesh Patel, Azadeh Patel, Manish Banker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Endometrium lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Implantation failure Medicine In patient lcsh:RG1-991 Endometrial receptivity array recurrent implantation failure Gynecology 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Retrospective cohort study personalized embryo transfer Abortion rate Embryo transfer Pregnancy rate 030104 developmental biology medicine.anatomical_structure Reproductive Medicine window of implantation Original Article business |
| Zdroj: | Journal of Human Reproductive Sciences Journal of Human Reproductive Sciences, Vol 12, Iss 1, Pp 59-66 (2019) |
| ISSN: | 1998-4766 0974-1208 |
| Popis: | Aims: This study aims to compare clinical outcomes in patients of recurrent implantation failure (RIF), who had embryo transfer (ET) following a receptive (R) endometrial receptivity array (ERA) and a personalized embryo transfer (pET) after a nonreceptive (NR) ERA. Settings and Design: This was a retrospective observational study. Study Period: July 2013–September 2017. Subjects and Methods: Two hundred and forty-eight patients having unexplained RIF who underwent ERA test were included in the study. Clinical outcomes were compared between patients having a receptive (R) ERA and those having a NR ERA who underwent a pET-based on ERA. Statistical Analysis Used: Chi-square and t-test. Results: ERA predicted receptive (R) endometrium at P + 5 in 82.3% (204/248) patients and NR in 17.7% (44/248) patients. Average failed previous in vitro fertilization cycles were 3.67 ± 1.67 among receptive ERA patients and 4.09 ± 1.68 among NR ERA patients. Pregnancy rate (PR), clinical PR, implantation rate (IR), abortion rate (AR), ongoing pregnancy rate (OPR), and cumulative PR were comparable between patients having receptive ERA who had a routine Embryo Transfer (ET) and those with an NR ERA who underwent a pET. Conclusions: ERA is helpful in identifying the window of implantation (WOI) through genetic expressions of the endometrium to pinpoint embryo transfer timing. pET guided by ERA in patients of RIF with displaced WOI improves IRs and OPRs. |
| Databáze: | OpenAIRE |
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