Intestinal Adenovirus Shedding Before Allogeneic Stem Cell Transplantation Is a Risk Factor for Invasive Infection Post-transplant
| Autor: | Gerhard Fritsch, Herbert Pichler, Bettina Berkowitsch, Karin Kosulin, Susanne Matthes, Thomas Lion, Ulrike Pötschger, Anita Lawitschka |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Time Factors 030106 microbiology Stem cell transplanted patients lcsh:Medicine Viremia Invasive infections Communicable Diseases General Biochemistry Genetics and Molecular Biology Virus Feces 03 medical and health sciences Species Specificity Risk Factors medicine Humans Transplantation Homologous Stool specimens Disseminated disease Viral shedding Risk factor lcsh:R5-920 Gastrointestinal tract business.industry Adenoviruses Human Incidence lcsh:R Human adenovirus virus diseases General Medicine medicine.disease eye diseases Virus Shedding Intestines Transplantation Kinetics surgical procedures operative 030104 developmental biology Multivariate Analysis Immunology Stem cell lcsh:Medicine (General) business Research Paper Stem Cell Transplantation |
| Zdroj: | EBioMedicine EBioMedicine, Vol 28, Iss C, Pp 114-119 (2018) |
| ISSN: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2017.12.030 |
| Popis: | Human adenoviruses (HAdV) are a major cause of morbidity and mortality in pediatric human stem cell transplant (HSCT) recipients. Our previous studies identified the gastrointestinal tract as a site of HAdV persistence, but the role of intestinal virus shedding pre-transplant for the risk of ensuing invasive infection has not been entirely elucidated. Molecular HAdV monitoring of serial stool samples using RQ-PCR was performed in 304 children undergoing allogeneic HSCT. Analysis of stool and peripheral blood specimens was performed pre-transplant and at short intervals until day 100 post-HSCT. The virus was detected in the stool of 129 patients (42%), and 42 tested positive already before HSCT. The patients displaying HAdV shedding pre-transplant showed a significantly earlier increase of intestinal HAdV levels above the critical threshold associated with high risk of invasive infection (p Highlights • Intestinal HAdV persistence confers an increased risk for invasive infection post-HSCT. • In HSCT-recipients with intestinal HAdV shedding, the virus levels mostly increase rapidly during the first days post-HSCT. • Monitoring of HAdV shedding before HSCT is important for identifying patients at high risk for early onset of viremia. |
| Databáze: | OpenAIRE |
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