Queueing theory model of mTOR complexes' impact on Akt-mediated adipocytes response to insulin

Autor:	Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul H. Davis, Ghada A. Soliman, Tadeusz A. Wysocki
Rok vydání:	2022
Předmět:	Multidisciplinary
Zdroj:	PloS one. 17(12)
ISSN:	1932-6203
Popis:	A queueing theory based model of mTOR complexes impact on Akt-mediated cell response to insulin is presented in this paper. The model includes several aspects including the effect of insulin on the transport of glucose from the blood into the adipocytes with the participation of GLUT4, and the role of the GAPDH enzyme as a regulator of mTORC1 activity. A genetic algorithm was used to optimize the model parameters. It can be observed that mTORC1 activity is related to the amount of GLUT4 involved in glucose transport. The results show the relationship between the amount of GAPDH in the cell and mTORC1 activity. Moreover, obtained results suggest that mTORC1 inhibitors may be an effective agent in the fight against type 2 diabetes. However, these results are based on theoretical knowledge and appropriate experimental tests should be performed before making firm conclusions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4128405099e972d75aa671d32d6d1db https://pubmed.ncbi.nlm.nih.gov/36574435 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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