Clinical Differences between COVID-19 and a COVID-Like Syndrome

Autor:	Antonella Tufano, Andrea Fontanella, Enrico Bernardi, Giuseppe Cardillo, Egidio Imbalzano, Giuseppe Camporese, Pierpaolo Di Micco, Vincenzo Russo
Přispěvatelé:	Di Micco, P., Camporese, G., Russo, V., Cardillo, G., Imbalzano, E., Tufano, A., Bernardi, E., Fontanella, A.
Rok vydání:	2021
Předmět:	medicine.medical_specialty Population Disease 030204 cardiovascular system & hematology Serology 03 medical and health sciences 0302 clinical medicine Internal medicine Pandemic Medicine 030212 general & internal medicine education education.field_of_study Lung SARS-CoV-2 business.industry Brief Report Risk of infection COVID-19 General Medicine medicine.disease Pneumonia medicine.anatomical_structure Cohort Atypical COVID-19 clinical presentation COVID-like syndrome Nasopharyngeal swab business
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2519, p 2519 (2021)
ISSN:	2077-0383
DOI:	10.3390/jcm10112519
Popis:	COVID-19 is an infection due to SARS-CoV-2; this virus has been identified as the cause of the present pandemic. Several typical characteristics are present in this infection, in particular pneumonia with possible lung failure, but atypical clinical presentations are being described daily by physicians around the world. Ground-glass opacities with pneumonia are the most common and dangerous presentations of the COVID-19 disease, and they are usually associated with positive nasopharyngeal swab (NPS) tests with detectable SARS-CoV-2 viral RNA. Compared to the general population, hospital workers have been at a greater risk of infection ever since the first patients were hospitalized. However, hospital workers have also been reported as having COVID-like symptoms despite repeated negative swab tests but having tested positive for SARS-CoV-2 antibodies with serological tests. We can postulate that a COVID-like syndrome is possible, in particular in hospital workers, that is characterized by symptoms similar to those of COVID-19, but with repeated negative nasopharyngeal swabs. These repeated negative NSPs make the difference in daily clinical management with people that experienced a single false negative nasopharyngeal swab; furthermore, a clear clinical differentiation of these situations is still lacking in the literature. For this reason, here, we report our main findings from a cohort of patients with a COVID-like syndrome compared to a similar group affected by typical COVID-19.
Databáze:	OpenAIRE
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