Exposure to Short-Lasting Impulse Noise Causes Neuronal c-Jun Expression and Induction of Apoptosis in the Adult Rat Brain
| Autor: | Kenneth G. Haglid, Hans-Arne Hansson, Shi Jingshan, Annette Säljö, Feng Bao, Anders Hamberger |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Proto-Oncogene Proteins c-jun Central nervous system Apoptosis Brain damage Biology Head Injuries Closed Internal medicine In Situ Nick-End Labeling medicine Animals Rats Wistar Cerebral Cortex Temporal cortex TUNEL assay Dentate gyrus c-jun Immunohistochemistry Rats Endocrinology medicine.anatomical_structure nervous system Cerebral cortex Brain Injuries Female Neurology (clinical) medicine.symptom Noise Immediate early gene Neuroscience |
| Zdroj: | Journal of Neurotrauma. 19:985-991 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/089771502320317131 |
| Popis: | Exposure to impulse noise, above a certain intensity, is harmful to auditory function. Effects of impulse noise on the central nervous system (CNS) are largely unexplored, and there is little information on critical threshold values and time factors. We have recently shown that neurofilament proteins are affected in the cerebral cortex and the hippocampus. Now we show that impulse noise induces expression of the immediate early gene c-Jun products, proposed to play a role in the initiation of neuronal death, and apoptosis as revealed by TUNEL staining. Rat brains were investigated immunohistochemically 2 h to 21 days after exposure to impulse noise of 198 dB or 202 dB. c-Jun was expressed in neuronal perikarya in layers II-VI of the temporal cortex, the cingulate and the piriform cortices at 2 h to 21 days after both exposure levels. Granule neurons of the dentate gyrus and the CA1-3 in the hippocampus pyramidal neurons were similarly affected. The elevated expression of c-Jun products remained high at all postexposure times. TUNEL staining was positive among the same nerve cell populations 6 h after exposure and persisted even at 7 days at both exposure levels. |
| Databáze: | OpenAIRE |
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