Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy

Autor:	Kamila Poláková, Evzen Ruzicka, Robert Jech, Radim Krupicka, Hana Brozova, Vaclav Cejka, Ondrej Klempir, Jan Mehnert, Zoltan Szabo
Rok vydání:	2019
Předmět:	Deep brain stimulation Parkinson's disease Health Toxicology and Mutagenesis medicine.medical_treatment Biomedical Engineering General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Gait (human) Neuroimaging Artificial Intelligence Cortex (anatomy) medicine General Pharmacology Toxicology and Pharmaceutics General Immunology and Microbiology business.industry General Neuroscience General Medicine medicine.disease nervous system diseases 030205 complementary & alternative medicine Subthalamic nucleus surgical procedures operative medicine.anatomical_structure nervous system 030220 oncology & carcinogenesis Finger tapping General Agricultural and Biological Sciences business Neuroscience Motor cortex
Zdroj:	Journal of Applied Biomedicine
ISSN:	1214-0287 1214-021X
DOI:	10.32725/jab.2019.014
Popis:	Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40e7f91bfc5ffd64007a2ad2a3f86ff https://doi.org/10.32725/jab.2019.014 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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