Effect of sub-lethal doses of Bacillus thuringiensis subsp. Aizawai and deltamethrin with regard to fertility and organ toxicity in pregnant albino rats
| Autor: | Valéria Wanderley-Teixeira, José Vargas de Oliveira, Herbert A.A. Siqueira, Edson João da Silva, Álvaro Aguiar Coelho Teixeira, Frederico C.L. Maia, Ana Janaína Jeanine Martins de Lemos |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology Insecticides media_common.quotation_subject Bacterial Toxins Physiology Fertility Toxicology Kidney Pathology and Forensic Medicine chemistry.chemical_compound Pregnancy Bacillus thuringiensis Nitriles Pyrethrins medicine Animals Protein Precursors Rats Wistar Chronic toxicity Lung media_common biology Dose-Response Relationship Drug Cell Biology General Medicine biology.organism_classification medicine.disease Rats medicine.anatomical_structure Deltamethrin chemistry Liver Organ Specificity Toxicity Abdomen Histopathology Female |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 65(5) |
| ISSN: | 1618-1433 |
| Popis: | Products with Bacillus thuringiensis (Bt) and synthetic insecticides have been widely used against important vectors of human diseases. However, few studies have addressed the application of these substances on the female reproduction apparatus during pregnancy at doses that do not cause clinical symptoms of intoxication. Seventy pregnant albino rats were analyzed with regard to fertility and histopathology of the kidneys, liver and lungs as well as the morphology of the neonates. The rats were submitted to three sub-lethal doses of the biological insecticide XenTari® WG (B. thuringiensis subsp. Aizawai) and the synthetic insecticide deltamethrin (Decis® 25CE). After the confirmation of copulation, the insecticides were administered orally for either seven days or during the entire pregnancy. The analysis revealed histopathological alterations in all organs analyzed in both treatments. No miscarriages occurred and the neonates did not exhibit signs of malformation of the head, limbs, thorax or abdomen. However, there were a smaller number of pups in the groups that received higher doses of the insecticides in comparison to the control group. Both insecticides produced similar lesions in the kidneys, liver and lungs and reduced the fertility of rats when administered at sub-lethal doses with no clinical signs of intoxication. Thus, this study suggests that sublethal doses of both insecticides can provide chronic toxicity in humans. |
| Databáze: | OpenAIRE |
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