Association between lipids, lipoproteins composition of HDL particles and triglyceride-rich lipoproteins, and LCAT and CETP activity in post-renal transplant patients

Autor: Andrzej Książek, Jerzy Bylina, Magdalena Hałabiś, Elżbieta Kimak, Janusz Solski, Iwona Baranowicz-Gąszczyk
Rok vydání: 2013
Předmět:
Male
Apolipoprotein B
Biochemistry
Phosphatidylcholine-Sterol O-Acyltransferase
chemistry.chemical_compound
apoB
apoCIII
apoCIIInonB
biology
General Medicine
Middle Aged
apoB-containing apoCIII
hsCRP
Renal transplant
Apolipoprotein (apo)AI
Acyltransferase
lipids (amino acids
peptides
and proteins)
Female
Lipoproteins
HDL
Adult
medicine.medical_specialty
Statin
medicine.drug_class
apoB-containing apoAII
LCAT
Biophysics
Young Adult
Internal medicine
Cholesterylester transfer protein
CETP
medicine
Humans
Triglycerides
Aged
Original Paper
Triglyceride
Cholesterol
Hypertriglyceridemia
nutritional and metabolic diseases
Cell Biology
medicine.disease
Kidney Transplantation
Cholesterol Ester Transfer Proteins
apoAII
Endocrinology
chemistry
biology.protein
Hydroxymethylglutaryl-CoA Reductase Inhibitors
apoAIInonB
Lipoprotein
Zdroj: Cell Biochemistry and Biophysics
ISSN: 1559-0283
Popis: High-density lipoprotein (HDL) remodeling within the plasma compartment and the association between lecithin-cholesterol acyltransferase (LCAT) and cholesterol ester transfer protein (CETP) activity, and lipid, lipoprotein concentrations and composition were investigated. The aim was to examine the high sensitivity of C-reactive protein (hsCRP), lipid, apolipoprotein B (apoB), apoAI, total apoAII, apoAIInonB, apoB-containing apoAII (apoB:AII), total apoCIII, apoCIIInonB, apoB-containing apoCIII (apoB:CIII) concentration and LCAT and CETP activity to gain an insight into the association between them and LCAT and CETP, 57 post-renal transplant (Tx) patients with and without statin therapy and in 15 healthy subjects. Tx patients had moderate hypertriglyceridemia, hypercholesterolemia, and dyslipoproteinemia, disturbed triglyceride-rich lipoproteins (TRLs) and HDL composition, decreased LCAT, and slightly increased hsCRP but no CETP activity. Spearman’s correlation test showed the association between lipids and lipoproteins and LCAT or CETP, and multiple ridge stepwise forward regression showed that immunosuppressive therapy in Tx patients can disturb HDL and TRLs composition. The results suggest that inhibition or activation of LCAT is due, in part, to HDL-associated lipoprotein. Lipoprotein composition of apoAI, apoAIInonB, and apoCIIInonB in HDL particle and apoB:AII TRLs can contribute to decrease LCAT mass in Tx patients. Tx patients without statin and with lower triglycerides but higher HDL cholesterol concentration and disturbed lipoprotein composition of ApoAI and apoAII in HDL particle can decrease LCAT, increase LDL cholesterol, aggravate renal graft, and accelerate atherosclerosis and chronic heart diseases.
Databáze: OpenAIRE
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