Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study)
| Autor: | Caroline Kreuzinger, Jalid Sehouli, Silvia Darb-Esfahani, Ignace Vergote, Mandy Stanske, Elena Ioana Braicu, Ilary Ruscito, Alexander Mustea, Iulia Ignat, Hani Gabra, Dan Cacsire Castillo-Tong, Mirjana Kessler, Pierluigi Benedetti Panici, Hagen Kulbe, Jacek Glajzer, Adriaan Vanderstichele, Marianna Nuti, Charlie Gourley, Fabian Trillsch, Eliane T Taube |
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| Přispěvatelé: | Commission of the European Communities |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine CD31 Oncology Cancer Research Angiogenesis BRCA Neovascularization angiogenesis 0302 clinical medicine microvessel density Cystadenocarcinoma Ovarian Neoplasms Neovascularization Pathologic BRCA1 Protein WOMEN Middle Aged CHEMOTHERAPY VEGF 3. Good health Gene Expression Regulation Neoplastic Platelet Endothelial Cell Adhesion Molecule-1 ovarian cancer 030220 oncology & carcinogenesis MVD Disease Progression cardiovascular system SURVIVAL Immunohistochemistry Female medicine.symptom Life Sciences & Biomedicine medicine.drug Adult EPITHELIAL OVARIAN medicine.medical_specialty Bevacizumab CARCINOMA BEVACIZUMAB bevacizumab survival Disease-Free Survival Article 03 medical and health sciences Lymphocytes Tumor-Infiltrating Internal medicine Biomarkers Tumor medicine Humans HGSOC BRCA2 MUTATIONS 1112 Oncology and Carcinogenesis Oncology & Carcinogenesis Aged Science & Technology business.industry Ovary medicine.disease Cystadenocarcinoma Serous 030104 developmental biology Microvessels CELLS PROGNOSTIC-FACTOR Neoplasm Grading Neoplasm Recurrence Local business Ovarian cancer CD8 |
| Zdroj: | British Journal of Cancer Ruscito, I, Cacsire Castillo-Tong, D, Vergote, I, Ignat, I, Stanske, M, Vanderstichele, A, Glajzer, J, Kulbe, H, Trillsch, F, Mustea, A, Kreuzinger, C, Benedetti Panici, P, Gourley, C, Gabra, H, Nuti, M, Taube, E T, Kessler, M, Sehouli, J, Darb-Esfahani, S & Ioana Braicu, E 2018, ' Characterisation of tumor microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact. An OCTIPS Consortium study. ', British Journal of Cancer . https://doi.org/10.1038/s41416-018-0157-z |
| Popis: | BACKGROUND: High-grade serous ovarian cancer (HGSOC) intratumoural vasculature evolution remains unknown. The study investigated changes in tumour microvessel density (MVD) in a large cohort of paired primary and recurrent HGSOC tissue samples and its impact on patients' clinico-pathological outcome. METHODS: A total of 222 primary (pOC) and recurrent (rOC) intra-patient paired HGSOC were assessed for immunohistochemical expression of angiogenesis-associated biomarkers (CD31, to evaluate MVD, and VEGF-A). Expression profiles were compared between pOCs and rOCs and correlated with patients' data. RESULTS: High intratumoural MVD and VEGF-A expression were observed in 75.7% (84/111) and 20.7% (23/111) pOCs, respectively. MVDhigh and VEGF(+) samples were detected in 51.4% (57/111) and 20.7% (23/111) rOCs, respectively. MVDhigh/VEGF(+) co-expression was found in 19.8% (22/111) and 8.1% (9/111) of pOCs and rOCs, respectively (p = 0.02). Pairwise analysis showed no significant change in MVD (p = 0.935) and VEGF-A (p = 0.121) levels from pOCs to rOCs. MVDhigh pOCs were associated with higher CD3(+) (p = 0.029) and CD8(+) (p = 0.013) intratumoural effector TILs, while VEGF(+) samples were most frequently encountered among BRCA-mutated tumours (p = 0.019). Multivariate analysis showed VEGF and MVD were not independent prognostic factors for OS. CONCLUSIONS: HGSOC intratumoural vasculature did not undergo significant changes during disease progression. High concentration of CD31(+) vessels seems to promote recruitment of effector TILs. The study also provides preliminary evidence of the correlation between VEGF-positivity and BRCA status. ispartof: BRITISH JOURNAL OF CANCER vol:119 issue:3 pages:330-338 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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