Hydrochlorothiazide-induced thrombocytopenic purpura
| Autor: | Cynthia Griffin, Peter M. Ngole, Kingsley C. Okafor |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Anorexia 030226 pharmacology & pharmacy Gastroenterology Malaise 03 medical and health sciences 0302 clinical medicine Hydrochlorothiazide Internal medicine Medicine Humans Pharmacology (medical) Platelet 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Aged business.industry medicine.disease Thrombocytopenic purpura Surgery Purpura Purpura Thrombocytopenic Toxicity medicine.symptom Diuretic business medicine.drug |
| Zdroj: | Drug intelligenceclinical pharmacy. 20(1) |
| ISSN: | 0012-6578 |
| Popis: | A case of thrombocytopenic purpura caused by hydrochlorothiazide is reported. A 65-year-old man received hydrochlorothiazide 50 mg/d to control his mild hypertension. Approximately one year after initiation of therapy, the patient developed epistaxis and generalized malaise with anorexia. A peripheral blood smear showed a reduction in platelets. The drug was discontinued; two weeks later the patient's symptoms resolved completely and his platelet count returned to normal. The results of several experiments suggest a mechanism of sensitivity, i.e., an antigen-antibody type of reaction. Hydrochlorothiazide therapy should be stopped if thrombocytopenic purpura develops. If recognized early, the symptoms will resolve spontaneously. The use of corticosteroids may aid in shortening the duration of thrombocytopenia. |
| Databáze: | OpenAIRE |
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