The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population
| Autor: | Qi-Lin Ma, Bin Cai, Sui-Jun Tong, Wei Wei, Yi-Hong Zhan, Ling Fang, Yi Lin, Ning Wang, Cong-Xia Lu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
China Aging medicine.medical_specialty Physiology Epidemiology Genome-wide association study Single-nucleotide polymorphism Polymorphism Single Nucleotide Brain Ischemia Internal medicine Diabetes mellitus Ischaemic stroke Genotype Ethnicity Genetics Humans Medicine Genetic Predisposition to Disease Allele Chinese han Aged Genetic association business.industry Public Health Environmental and Occupational Health Middle Aged Atherosclerosis Cadherins medicine.disease Stroke Case-Control Studies Female business |
| DOI: | 10.6084/m9.figshare.3369745.v1 |
| Popis: | Recently, CELSR1 was identified by genome-wide association studies (GWAS) as a susceptibility gene for ischaemic stroke (IS) in Japanese individuals.The goal was to examine whether CELSR1 variants are associated with IS in the Chinese Han population.This study genotyped two single nucleotide polymorphisms (SNPs) of CELSR1, rs6007897 and rs4044210, in a Chinese sample of 569 IS cases and 581 controls and assessed their genotype and allele associations with IS.The results showed that rs6007897 and rs4044210 variants of CELSR1 were significantly (p 0.01) associated with IS. These associations remained after adjustment for age, gender, smoking status, hypertension, diabetes mellitus and hypercholesterolemia. In addition, a significant association was observed of rs6007897 and rs4044210 of CELSR1 with large artery atherosclerosis (LAA), a sub-type of IS (p 0.01).Taken together, the present study has proven for the first time that CELSR1 is a susceptibility gene for IS in the Chinese Han population, especially for LAA. |
| Databáze: | OpenAIRE |
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