Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia
| Autor: | E. Müldür, W. Hübl, Heinz Ludwig, G. Endler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Disease status medicine.medical_specialty Weakness Anemia Severity of Illness Index Pathogenesis Young Adult iron deficiency Internal medicine Neoplasms medicine Prevalence Humans Poor performance status chemotherapy-induced anemia Aged Aged 80 and over iron deficiency anemia Anemia Iron-Deficiency business.industry cancer-related anemia Cancer functional iron deficiency Hematology Iron deficiency Original Articles Middle Aged medicine.disease Oncology Iron-deficiency anemia Quality of Life and Supportive Care Immunology absolute iron deficiency Female medicine.symptom business |
| Zdroj: | Annals of Oncology |
| ISSN: | 1569-8041 0923-7534 |
| Popis: | Background Only limited data on the prevalence of iron deficiency (ID) and its correlation with clinical parameters are available in cancer. ID frequently contributes to the pathogenesis of anemia in patients with cancer and may lead to several symptoms such as impaired physical function, weakness and fatigue. Patients and methods Parameters of iron status and clinical parameters were evaluated in 1528 patients with cancer who presented consecutively within a four-month period at our center. One thousand fifty-three patients had solid tumors and 475 hematological malignancies. Results ID [transferrin saturation (TSAT) < 20%] was noted in 645 (42.6%) of the 1513 patients with TSAT tests available and 500 (33.0%) were anemic. ID rates were highest in pancreatic (63.2%), colorectal (51.9%) and lung cancers (50.7%). Of the 409 iron-deficient patients in whom serum ferritin levels were available additionally to TSAT, 335 (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin ≥30 ng/ml) and 74 (18.1%) with absolute ID. In patients with solid tumors, prevalence of ID correlated with cancer stage at diagnosis (P = 0.001), disease status (P = 0.001) and ECOG performance status (P = 0.005). Conclusions ID was frequently noted in cancer and was associated with advanced disease, close proximity to cancer therapy, and poor performance status in patients with solid tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|