A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study
Autor: | Adele M. Goman, Marilyn S. Albert, Melissa Minotti, Victoria A. Sanchez, Frank R. Lin, Michelle L. Arnold, Shrikant I. Bangdiwala, A. Richey Sharrett, Nancy W. Glynn, Theresa H. Chisolm, Sonia M. Davis, Ann C. Eddins, Elizabeth A. Rodgers, Nicholas S. Reed, Thomas H. Mosley, Josef Coresh, George W. Rebok, Jennifer A. Deal |
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Rok vydání: | 2017 |
Předmět: |
Gerontology
Longitudinal study Epidemiology Hearing loss Short Report Presbycusis law.invention 03 medical and health sciences Clinical trials Cognition 0302 clinical medicine Hearing Randomized controlled trial Memory law medicine Cognitive decline 030223 otorhinolaryngology Successful aging medicine.disease 3. Good health Clinical trial Psychiatry and Mental health Dementia Neurology (clinical) medicine.symptom Psychology 030217 neurology & neurosurgery |
Zdroj: | Alzheimer's & Dementia : Translational Research & Clinical Interventions |
ISSN: | 2352-8737 |
Popis: | Introduction Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254 . Results The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL. |
Databáze: | OpenAIRE |
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