Occupation and multiple myeloma: An occupation and industry analysis
| Autor: | Patricia Hartge, Richard K. Severson, Mark P. Purdue, Patricia A. Stewart, Aaron Blair, Laura S. Gold, Anneclaire J. De Roos, Noah S. Seixas, Scott Davis, Kevin Milliken |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Washington Gerontology Michigan medicine.medical_specialty Lymphoma Population Medicare Logistic regression Risk Assessment Article Risk Factors Occupational Exposure Epidemiology Humans Medicine Registries education Aged education.field_of_study Medicaid business.industry Standard Industrial Classification Public Health Environmental and Occupational Health Odds ratio Middle Aged United States Confidence interval Random digit dialing Logistic Models Case-Control Studies Female Multiple Myeloma business Risk assessment Demography |
| Zdroj: | American Journal of Industrial Medicine. |
| ISSN: | 1097-0274 0271-3586 |
| DOI: | 10.1002/ajim.20857 |
| Popis: | Background Multiple myeloma (MM) is an incurable plasma cell malignancy with a poorly understood etiology. The purpose of our research was to examine the relationships between lifetime occupations and MM in a relatively large case–control study. Methods MM cases (n = 180) were identified through cancer registries in the Seattle-Puget Sound area and Detroit. Population-based controls (n = 481) were identified using random digit dialing and Medicare and Medicaid Services files. In-person interviews were conducted to ascertain occupational histories. Standard occupational classification (SOC) and standard industrial classification (SIC) codes were assigned to each job held by each participant. Unconditional logistic regression was used to generate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between MM and having ever worked in each occupation/industry and according to duration of employment in an occupation/industry. Results The risk of MM was associated with several manufacturing occupations and industries, including machine operators and tenders, not elsewhere classified (SOC 76) (OR = 1.8, CI = 1.0–3.3); textile, apparel, and furnishing machine operators and tenders (SOC 765) (OR = 6.0, CI = 1.7–21); and machinery manufacturing, except electrical (SIC 35) (OR = 3.3, CI = 1.7–6.7). Several service occupations and industries, such as food and beverage preparation (SOC 521) (OR = 2.0, CI = 1.1–3.8), were also associated with MM. One occupation that has been associated with MM in several previous studies, painters, paperhangers, and plasterers (SOC 644) was associated with a non-significantly elevated risk (OR = 3.6, CI = 0.7–19). Conclusions We found associations between the risk of MM and employment in several manufacturing and service-related occupations and industries. Am. J. Ind. Med. 53:768–779, 2010. © 2010 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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