The association of intrauterine growth abnormalities in women with type 1 diabetes mellitus complicated by vasculopathy
| Autor: | Jane C. Khoury, Oormila Kovilam, Sina Haeri, Menachem Miodovnik |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy in Diabetics Gestational Age Comorbidity Nephropathy Pregnancy Internal medicine Diabetes mellitus Odds Ratio medicine Birth Weight Humans reproductive and urinary physiology Type 1 diabetes Fetal Growth Retardation Cesarean Section Obstetrics business.industry Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Odds ratio Infant Low Birth Weight medicine.disease Diabetes Mellitus Type 1 Endocrinology Premature Birth Small for gestational age Female business Diabetic Angiopathies Maternal Age Retinopathy |
| Zdroj: | American Journal of Obstetrics and Gynecology. 199:278.e1-278.e5 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2008.06.066 |
| Popis: | Objective The purpose of this study was to test whether vasculopathy in type 1 diabetes mellitus (DM) is associated with fetal growth abnormalities. Study Design Women with type 1 DM (n = 340) were enrolled in a prospective study of diabetes in pregnancy and classified according to vascular status: NV (no vasculopathy, n = 181), HBR (hypertension or background retinopathy, n = 79), PR (proliferative retinopathy only, n = 16), NEP (nephropathy only, n = 40), and PRN (proliferative retinopathy and nephropathy, n = 24). Association of vascular status with low birthweight (LBW) and small for gestational age (SGA) infants was analyzed. Results The odds ratios for delivery of a LBW infant compared to women without vasculopathy after controlling for maternal age, gestational age and race were: HBR 1.0, PR 2.2, NEP 3.7, and PRN 5.5. The odds ratios for delivery of a SGA infant were: HBR 0.7, PR 10.4, NEP 1.9, and PRN 9.9. Conclusion Diabetic vasculopathy is associated with increased odds for delivery of low-birthweight or SGA infants. |
| Databáze: | OpenAIRE |
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