Airway hyperresponsiveness to adenosine 5'-monophosphate in feline chronic inflammatory lower airway disease
| Autor: | Reinhard Hirt, Sarina Shibly, A. Galler, Andrea Bilek |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
Adenosine monophosphate Male medicine.medical_specialty Chronic bronchitis medicine.drug_class Cat Diseases chemistry.chemical_compound Internal medicine medicine Plethysmograph Animals Asthma Plethysmography Whole Body CATS General Veterinary Dose-Response Relationship Drug business.industry respiratory system medicine.disease Adenosine Adenosine Monophosphate Bronchitis Chronic Endocrinology chemistry Anesthesia Case-Control Studies Cats Bronchitis Animal Science and Zoology Female business medicine.drug |
| Zdroj: | Veterinary journal (London, England : 1997). 187(1) |
| ISSN: | 1532-2971 |
| Popis: | Airway hyperresponsiveness is a key feature of human asthma and chronic bronchitis and response to the indirectly acting agonist adenosine 5'-monophosphate (AMP) is thought to reflect underlying airway inflammation. To examine whether airway responsiveness testing (ART) with AMP may be used to differentiate healthy cats from those with asthma (FA) and chronic bronchitis (CB), 24 cats (9 FA, 6 CB, 9 controls) underwent ART with AMP at concentrations of 0.1, 1, 10, 100 and 500mg/mL using barometric whole body plethysmography. The defined endpoint of ART, an increase in enhanced pause (Penh) exceeding 300% of the post-saline value (baseline), was reached in 9/15 patients (7 FA, 2 CB), but in none of the controls. Mean Penh (±SD) at baseline (BL) was 0.49±0.16 for cases, and 0.54±0.16 for controls, and was significantly increased after AMP challenge in clinical cases (2.62±2.20), but not in controls (0.63±0.30, P |
| Databáze: | OpenAIRE |
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