Atypical Young-onset Dementia in Cerebral Thromboangiitis Obliterans: A Case Report
| Autor: | Na-Yeon Jung, Jae-Hyeok Lee, Chungsu Hwang, Kyoungjune Pak, Myung Jun Lee, Jin-Hong Shin, Jin A Yoon, Eric J. Huang, Jun Kyeung Ko, Young-Min Lee, Gi Yeong Huh, Kyung-Un Choi, Eun-Joo Kim, Jae Meen Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Yod Pathology medicine.medical_specialty Diagnosis Differential Neuroimaging Medicine Dementia Humans Vascular dementia Genetic testing medicine.diagnostic_test business.industry Dementia Vascular Parietal lobe Thromboangiitis Obliterans Syndrome medicine.disease Psychiatry and Mental health Clinical Psychology Young onset dementia Geriatrics and Gerontology Differential diagnosis business Gerontology |
| Zdroj: | Alzheimer disease and associated disorders. 36(2) |
| ISSN: | 1546-4156 |
| Popis: | Young-onset dementia (YOD, age at onset below 45 y) has a broad differential diagnosis. We describe a 41-year-old man with atypical manifestations of YOD syndrome in cerebral thromoboangiitis obliterans (CTAO). Extensive antemortem workup including clinical assessment, laboratory investigations, neuroimaging, and genetic testing did not elucidate a diagnosis. Postmortem neuropathologic examination revealed cortical sickle-shaped granular atrophy, resulting from numerous remote infarcts and cortical microinfarcts that mainly affected the bilateral frontal and parietal lobe, confirming CTAO. Although CTAO is a rare cause of vascular dementia, it should be considered as one of the differentials in patients with YOD with a history of heavy smoking and presence of symmetric damages of watershed-territory on neuroimaging. |
| Databáze: | OpenAIRE |
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