Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2
| Autor: | Didem Mumcuoglu, Eric Farrell, Anna Tampieri, Janneke Witte-Bouma, Tatiana Patrício, Monica Montesi, Shorouk Fahmy Garcia, Silvia Panseri, Monica Sandri, Simone Sprio |
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| Přispěvatelé: | Orthopedics and Sports Medicine, Oral and Maxillofacial Surgery, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
medicine.medical_treatment Iron Kinetics Hybrid superparamagnetic microspheres Bone Morphogenetic Protein 2 Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Pulsed electromagnetic field Microsphere Biomaterials bone regeneration Transforming Growth Factor beta Osteogenesis medicine Humans hybrid superparamagnetic microspheres Bone regeneration Growth factor Mesenchymal stem cell sustained release 021001 nanoscience & nanotechnology Nanocrystalline material Microspheres Recombinant Proteins 0104 chemical sciences osteogenesis rhBMP-2 Durapatite Chemical engineering pulsed electromagnetic field Mechanics of Materials Cell culture 0210 nano-technology Superparamagnetism Sustained release |
| Zdroj: | Materials Science & Engineering C-Biomimetic Materials Sensors and Systems, 119:111410. Elsevier Materials science & engineering. C, Biomimetic materials, sensors and systems (2021). info:cnr-pdr/source/autori:Tatiana M.Fernandes Patrício, Didem Mumcuoglu, Monica Montesi, Silvia Panseri, Janneke Witte-Bouma, Shorouk Fahmy Garcia, Monica Sandri, Anna Tampieri, Eric Farrell, Simone Sprio/titolo:Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2./doi:/rivista:Materials science & engineering. C, Biomimetic materials, sensors and systems (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 0928-4931 |
| Popis: | Hybrid superparamagnetic microspheres with bone-like composition, previously developed by a bio-inspired assembling/mineralization process, are evaluated for their ability to uptake and deliver recombinant human bone morphogenetic protein-2 (rhBMP-2) in therapeutically-relevant doses along with prolonged release pro- files. The comparison with hybrid non-magnetic and with non-mineralized microspheres highlights the role of nanocrystalline, nanosize mineral phases when they exhibit surface charged groups enabling the chemical linking with the growth factor and thus moderating the release kinetics. All the microspheres show excellent osteogenic ability with human mesenchymal stem cells whereas the hybrid mineralized ones show a slow and sustained release of rhBMP-2 along 14 days of soaking into cell culture medium with substantially bioactive effect, as reported by assay with C2C12 BRE-Luc cell line. It is also shown that the release extent can be modulated by the application of pulsed electromagnetic field, thus showing the potential of remote controlling the bioactivity of the new micro-devices which is promising for future application of hybrid biomimetic mi- crospheres in precisely designed and personalized therapies. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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