Inhibition of proliferation of lines derived from human cervical carcinomas by cytotoxic drugs and by recombinant interferons
| Autor: | Timothy L. Ratliff, Laurice Dawoud, Zsuzsanna Kovacs, Allan J. Jacobs |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Uterine Cervical Neoplasms
Biology law.invention Interferon-gamma law medicine Tumor Cells Cultured Cytotoxic T cell Humans Doxorubicin Drug Interactions Cytotoxicity Cisplatin Hpv types Dose-Response Relationship Drug Obstetrics and Gynecology Cell cycle Molecular biology Recombinant Proteins Oncology Cell culture Interferon Type I Recombinant DNA Carcinoma Squamous Cell Female Cell Division medicine.drug |
| Zdroj: | Gynecologic oncology. 32(1) |
| ISSN: | 0090-8258 |
| Popis: | The authors studied the effects of recombinant interferons (IFN), doxorubicin, and cisplatin against three cell lines derived from human epidermoid cervical carcinomas. These lines were SW 756, containing the genome of human papillomavirus (HPV) type 18, and CaSki and SiHa, containing HPV type 16. IFN-gamma suppressed the growth of all three lines, with a plateau in inhibitory effect beyond a concentration of 1000 units/ml. IFN-alpha was effective in this regard only against SW 756. In this line, the two IFNs together inhibited cell replication to a greater extent than the maximal effect of either IFN alone. Doxorubicin exerted a dose-dependent cytotoxic effect against all the lines, while cisplatin exhibited cytotoxicity only against SW 756. Doxorubicin and IFN-gamma, when used together, acted synergistically against CaSki and SiHa, and in an additive manner against SW 756. |
| Databáze: | OpenAIRE |
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