Age-related Alterations in Swallowing Biomechanics
| Autor: | Miranda J. Cullins, Heidi Kletzien, Nadine P. Connor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging Video Recording Biochemistry Article 03 medical and health sciences 0302 clinical medicine Endocrinology Swallowing stomatognathic system Tongue Genetics medicine otorhinolaryngologic diseases Image Processing Computer-Assisted Animals Molecular Biology Mastication business.industry Swallowing Disorders digestive oral and skin physiology Biomechanics Soft tissue Cell Biology Anatomy Dysphagia Biomechanical Phenomena Deglutition Rats 030104 developmental biology medicine.anatomical_structure Fluoroscopy Models Animal medicine.symptom business Deglutition Disorders 030217 neurology & neurosurgery Vertebral column |
| Popis: | Background Aging rodent models allow for the discovery of underlying mechanisms of cranial muscle dysfunction. Methods are needed to allow quantification of complex, multivariate biomechanical movements during swallowing. Videofluoroscopic swallow studies (VSS) are the standard of care in assessment of swallowing disorders in patients and validated quantitative, kinematic, and morphometric analysis methods have been developed. Our purpose was to adapt validated morphometric techniques to the rodent to computationally analyze swallowing dysfunction in the aging rodent. Methods VSS, quantitative analyses (bolus area, bolus velocity, mastication rate) and a rodent specific multivariate, morphometric computational analysis of swallowing biomechanics were performed on 20 swallows from 5 young adult and 5 old Fischer 344/Brown Norway rats. Eight anatomical landmarks were used to track the relative change in position of skeletal levers (cranial base, vertebral column, mandible) and soft tissue landmarks (upper esophageal sphincter, base of tongue). Results Bolus area significantly increased and mastication rate significantly decreased with age. Aging accounted for 77.1% of the variance in swallow biomechanics, and 18.7% of the variance was associated with swallow phase (oral vs pharyngeal). Post hoc analyses identified age-related alterations in tongue base retraction, mastication, and head posture during the swallow. Conclusion Geometric morphometric analysis of rodent swallows suggests that swallow biomechanics are altered with age. When used in combination with biological assays of age-related adaptations in neuromuscular systems, this multivariate analysis may increase our understanding of underlying musculoskeletal dysfunction that contributes to swallowing disorders with aging. |
| Databáze: | OpenAIRE |
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