Selective effects of fetal alcohol exposure on rat thymocyte development
| Autor: | Susan H. Tritt, Anna N. Taylor, Delia Tio, Michelle L. Pilati, Francesco Chiappelli |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Health (social science) CD3 Complex Ontogeny T-Lymphocytes Transferrin receptor Stimulation Cytoplasmic receptor Toxicology Lymphocyte Activation Biochemistry Rats Sprague-Dawley Behavioral Neuroscience Fetus Receptors Glucocorticoid Pregnancy Internal medicine medicine Concanavalin A Animals Receptor biology Ethanol General Medicine Rats Thymocyte Endocrinology Neurology biology.protein Female Glucocorticoid medicine.drug |
| Zdroj: | Alcohol (Fayetteville, N.Y.). 9(6) |
| ISSN: | 0741-8329 |
| Popis: | The thymoproliferative response to concanavalin A (ConA) following fetal alcohol exposure (FAE) is higher than control (149%) on day 44, is lower than control (64%) by day 51, and normalizes by day 69 (88% of controls). The ontogeny of HLA-Dr and transferrin receptor (CD71) expression in response to anti-CD3 stimulation is similar among the groups, but is distinct from that of ConA proliferation. The ontogeny of glucocorticoid cytoplasmic receptor (GCCR) sites per thymocyte is also different from the ontogeny of the ConA response. The number of GCCR sites rises sharply (2.5-fold) in control rat thymocytes between days 30 and 44, and remains at that level at later time points. By contrast, the number of GCCR sites per FAE thymocytes rises nearly linearly and normalizes by day 72. Our data support the notion that prenatal alcohol exposure significantly alters thymic development and indicates that the relationship between the development of thymocyte functional responses and that of GCCR is more complex than initially hypothesized. |
| Databáze: | OpenAIRE |
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