Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
| Autor: | Leonardo Oliveira Trivilin, Anderson Barros Archanjo, Aline Ribeiro Borçoi, Rafael Assis de Souza, Flávia Vitorino Freitas, Mayara Mota de Oliveira, José Claudio Casali-da-Rocha, Suzanny Oliveira Mendes, Juliana Krüger Arpini, Tamires dos Santos Vieira, Lidia Maria Rebolho Batista Arantes, Iúri Drumond Louro, Joaquim Gasparini dos Santos, Wagner Miranda Barbosa, Julia de Assis Pinheiro, Bruna Pereira Sorroche, Dirceu Pereira dos Santos, Elizeu Borloti, Adriana Madeira Álvares-da-Silva, Catarine Lima Conti |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Alcohol Drinking Science Physiology Overweight Article 03 medical and health sciences Young Adult 0302 clinical medicine Glucocorticoid receptor Receptors Glucocorticoid Epigenetics and behaviour medicine Humans Epigenetics Genetic Association Studies Multidisciplinary DNA methylation business.industry Depression Stressor Methylation Middle Aged medicine.disease Personality disorders Cortisone 030104 developmental biology Cross-Sectional Studies Socioeconomic Factors Medicine Anxiety CpG Islands Female Disease Susceptibility medicine.symptom business Body mass index 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| Popis: | The NR3C1 glucocorticoid receptor (GR) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. NR3C1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. Previous studies have reported that stressful events are involved in NR3C1 gene methylation, suggesting that its regulation under environmental effects is complex. The present study aimed to analyze associations involving stressors such as socioeconomic status, health conditions, and lifestyle in relation to NR3C1 methylation in adults. This study included 386 individual users of the Brazilian Public Unified Health System (SUS), and evaluated socioeconomic and health conditions, body mass index, cortisol levels, and lifestyle. Data were correlated with NR3C1 methylation, determined using DNA pyrosequencing. The results showed that alcohol consumption, overweight, and high cortisol levels were related to NR3C1 demethylation, while depression was related to its methylation. Habits, lifestyle, and health status may influence NR3C1 gene regulation via methylation, revealing the complexity of environmental impacts on NR3C1 methylation. |
| Databáze: | OpenAIRE |
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