The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals
| Autor: | Viktor Wottschel, Alfa Study, Gemma Salvadó, Linda Mazzai, Betty M. Tijms, Carles Falcon, Frederik Barkhof, Carole H. Sudre, Silvia Ingala, Anna Brugulat-Serrat, José Luis Molinuevo, Juan Domingo Gispert, Grégory Operto |
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| Přispěvatelé: | Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Neurology |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Male Aging medicine.medical_specialty Genotype 03 medical and health sciences 0302 clinical medicine Atrophy Apolipoproteins E Cognition Alzheimer Disease Internal medicine Medicine Humans Effects of sleep deprivation on cognitive performance Genetic Association Studies Aged Cerebral Hemorrhage Aged 80 and over medicine.diagnostic_test business.industry General Neuroscience Homozygote Age Factors Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging White Matter 030104 developmental biology White matter hyperintensity Cohort Cardiology lipids (amino acids peptides and proteins) Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Ingala, S, Mazzai, L, Sudre, C H, Salvadó, G, Brugulat-Serrat, A, Wottschel, V, Falcon, C, Operto, G, Tijms, B, Gispert, J D, Molinuevo, J L, Barkhof, F & ALFA Study 2020, ' The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle-and old-aged individuals ', Neurobiology of Aging, vol. 95, pp. 104-114 . https://doi.org/10.1016/j.neurobiolaging.2020.06.015 Neurobiology of Aging, 95, 104-114. Elsevier Inc. |
| ISSN: | 1558-1497 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2020.06.015 |
| Popis: | Positive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of APOE genotype on CMBs in a cohort of cognitively unimpaired middle- and old-aged individuals enriched for APOE-ε4 genotype. Participants from ALFA (Alzheimer and Families) cohort were included and their magnetic resonance scans assessed (n = 564, 50% APOE-ε4 carriers). Quantitative magnetic resonance analyses included visual ratings, atrophy measures, and white matter hyperintensity (WMH) segmentations. The prevalence of CMBs was 17%, increased with age (p < 0.05), and followed an increasing trend paralleling APOE-ε4 dose. The number of CMBs was significantly higher in APOE-ε4 homozygotes compared to heterozygotes and non-carriers (p < 0.05). This association was driven by lobar CMBs (p < 0.05). CMBs co-localized with WMH (p < 0.05). No associations between CMBs and APOE-ε2, gray matter volumes, and cognitive performance were found. Our results suggest that cerebral vessels of APOE-ε4 homozygous are more fragile, especially in lobar locations. Co-occurrence of CMBs and WMH suggests that such changes localize in areas with increased vascular vulnerability. |
| Databáze: | OpenAIRE |
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