Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients
| Autor: | Xiao-Ying Sun, Li-xue Zhou, Shu-hua Ma, Na Di, Ling-Min Liao, Xin Zhang, Ruike Pan, Nan Zhou, Yu-Feng Ren |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Pathology Epidemiology Uterine Cervical Neoplasms lcsh:Medicine Cervical Cancer Young adult Carcinoma Small Cell lcsh:Science Aged 80 and over Multidisciplinary biology Cancer Risk Factors Chromogranin A Obstetrics and Gynecology Middle Aged Prognosis medicine.anatomical_structure Meta-analysis Immunohistochemistry Medicine Female Research Article Adult medicine.medical_specialty China Adolescent Small-cell carcinoma Young Adult Diagnostic Medicine Internal medicine medicine Carcinoma Humans Cervix Aged Retrospective Studies business.industry lcsh:R Gynecologic Cancers Cancers and Neoplasms Retrospective cohort study medicine.disease Biomarker Epidemiology biology.protein lcsh:Q business Gynecological Tumors Biomarkers General Pathology |
| Zdroj: | PLoS ONE, Vol 7, Iss 4, p e33674 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Small cell carcinoma of the cervix (SCCC) is a very rare tumor. Due to its rarity and the long time period, there is a paucity of information pertaining to prognostic factors associated with survival. The objective of this study was to determine whether clinicopathologic finings or immunohistochemical presence of molecular markers predictive of clinical outcome in patients with SCCC. METHODOLOGY AND FINDINGS: We retrospectively reviewed a total of 293 patients with SCCC (47 patients from Cancer Center of Sun Yat-sen University in china, 71 patients from case report of china journal, 175 patients from case report in PubMed database). Of those 293 patients with SCCC, the median survival time is 23 months. The 3-year overall survival rates (OS) and 3-year disease-free survival rates (DFS) for all patients were 34.5% and 31.1%, respectively. Univariate and multivariate analysis showed that FIGO stage (IIb-IV VS I-IIa, Hazard Ratio (HR) = 3.08, 95% confidence interval (CI) of ratio = [2.05, 4.63], P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|