The effects of chlormadinone acetate (CMA), antiandrogen, on the pituitary, testis, prostate and adrenal gland of the dog with spontaneous benign prostatic hyperplasia
| Autor: | Rie Ikeda, Norio Fukui, Masanori Murakoshi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pituitary gland Chlormadinone Acetate medicine.drug_class Prostatic Hyperplasia Toxicology Antiandrogen chemistry.chemical_compound Chlormadinone acetate Dogs Adrenocorticotropic Hormone Prostate Internal medicine Adrenal Glands Testis medicine Animals Fluorescent Antibody Technique Indirect business.industry Adrenal gland Androgen Antagonists Organ Size Luteinizing Hormone Hyperplasia medicine.disease Immunohistochemistry medicine.anatomical_structure Endocrinology chemistry Receptors Androgen Pituitary Gland Benign prostatic hyperplasia (BPH) business Chlormadinone |
| Zdroj: | The Journal of Toxicological Sciences. 26:119-127 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.26.119 |
| Popis: | The effect of chlormadinone acetate (CMA), a synthetic steroidal antiandrogen, on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Male beagle dogs (5-8 years old) were divided into four experimental groups. Group 1 consisted of untreated controls. Groups 2 and 3 received CMA 0.03 and 0.1 mg/kg/day, p.o., respectively, for 6 months. In group 1, glandular hyperplasia of the prostate was clearly detected. The glandular epithelial cells showed uniformly intense nuclear staining for androgen receptor (AR). AR was also localized in the nuclei of the fibro-muscular stromal cells. In groups 2 and 3, CMA produced marked atrophy of the glandular epithelium. The interacinar fibro-muscular stroma was prominent. The nuclear staining for AR in both epithelial and stromal cells was remarkably decreased. In addition, a histopathological study showed that CMA medication for 6 months exerted no effect on the testes and adrenal glands or on immunoreactive positive cells to LH- and ACTH-antibody (pituitary LH- and ACTH-cells). Therefore, it is concluded that CMA (0.03 and 0.1 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes, adrenal glands or pituitary LH- and ACTH-cells. |
| Databáze: | OpenAIRE |
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