Near-full genome characterization of unclassified hepatitis c virus strains relating to genotypes 1 and 4

Autor: Demetriou, Victoria L., Kostrikis, Leontios G.
Přispěvatelé: Kostrikis, Leontios G. [0000-0002-5340-7109]
Rok vydání: 2011
Předmět:
Male
virus strain
gene amplification
genotype
Hepacivirus
medicine.disease_cause
Genome
chemistry.chemical_compound
genetic variability
Genotype
Cluster Analysis
peginterferon
Phylogeny
genome analysis
Aged
80 and over
unclassified Hepatitis C virus
Genetics
virus isolation
Hepatitis C virus
Reverse Transcriptase Polymerase Chain Reaction
adult
Strain (biology)
article
Middle Aged
virus transmission
Hepatitis C
aged
female
Infectious Diseases
RNA
Viral
Female
genetic trait
Phylogenetic relationship
Adult
ribavirin
Sequence analysis
Molecular Sequence Data
gene sequence
Genome
Viral
Biology
multiple cycle treatment
reverse transcription polymerase chain reaction
male
Phylogenetics
Virology
medicine
Humans
case report
human
molecular phylogeny
Aged
nonhuman
nucleotide sequence
Near-full genome sequencing
Sequence Analysis
DNA
virus genome
chemistry
Cyprus
HCV subtype classification
hepatitis C
DNA
Zdroj: Journal of medical virology
J.Med.Virol.
ISSN: 0146-6615
Popis: Near-full genome sequences are presented in this report for the first time of unclassified HCV strains amplified using RT-PCR from plasma of patients living in Cyprus. One strain appears to be a unique genotype-1-like isolate, displaying closer phylogenetic relationship to genotype 1 strains than other genotypes. Two isolates representing an unclassified variant of genotype 4 were also amplified, cases of which have been found elsewhere in the world in patients of central African origin and could now be assigned provisionally as new subtype 4v. The near-full genome nucleotide sequences of unclassified HCV isolates provide reference sequences of variants unknown previously, and contribute to the publicly available HCV sequence data to be used for diagnosis or research. © 2011 Wiley Periodicals, Inc. 83 2119 2127 Cited By :5
Databáze: OpenAIRE
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