Treatment of sarcoid granulomatous interstitial nephritis with adalimumab
| Autor: | Jack Moore, Tulsi Mehta, Roopali Gupta, Lisa Beaudet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Transplantation
Kidney Systemic disease Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Renal function Case Report medicine.disease urologic and male genital diseases medicine.anatomical_structure TNF-alpha inhibitors Nephrology adalimumab Biopsy medicine Adalimumab Renal biopsy Sarcoidosis sarcoidosis business Nephritis medicine.drug granulomatous interstitial nephritis |
| Zdroj: | NDT Plus |
| ISSN: | 1753-0792 1753-0784 |
| Popis: | Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. After therapy with adalimumab, her renal function improved with a significant reduction in proteinuria. Repeat kidney biopsy showed resolution of renal granulomata. To our knowledge, this is the first report of successful treatment of granulomatous interstitial nephritis with adalimumab. |
| Databáze: | OpenAIRE |
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