Ruthenium-Catalyzed Metathesis Cascade Reactions in Natural Products Synthesis
| Autor: | Jing-Chun Han, Chuang-Chuang Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
General Chemical Engineering
chemistry.chemical_element 010402 general chemistry Metathesis 01 natural sciences Biochemistry Securinega Catalysis Ruthenium Lactones chemistry.chemical_compound Alkaloids Cascade reaction Materials Chemistry Organic chemistry Biological Products Natural product biology 010405 organic chemistry Chemistry Total synthesis General Chemistry biology.organism_classification 0104 chemical sciences Cyclization Cascade Sesquiterpenes |
| Zdroj: | The Chemical Record. 17:499-517 |
| ISSN: | 1527-8999 |
| DOI: | 10.1002/tcr.201600110 |
| Popis: | In this account, we provide a brief summary of recent developments in ruthenium-catalyzed metathesis cascade reactions towards the total synthesis of natural products. We also highlight recent progress from our own laboratory regarding the synthesis of securinega alkaloids and humulanolides, which has resulted in the development of novel ruthenium-catalyzed metathesis cascade reactions. Inspired and guided by the pioneering and elegant research conducted in this area, we developed a regio-controlled relay dienyne metathesis cascade reaction and a cyclobutene-promoted RCM/ROM/RCM cascade reaction for the synthesis of securinega alkaloids and humulanolides, respectively. |
| Databáze: | OpenAIRE |
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