Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

Autor: Florence Desvard, Françoise Levasseur, Sébastien Bertil, Tristan Mirault, David M. Smadja, Olivier Bory, Benjamin Planquette, Nicolas Peron, Benjamin Terrier, Jérôme Duchemin, Cherifa Cheurfa, Christophe Peronino, Agathe Beauvais, Frédéric Pène, Bertrand Hermann, Coralie L. Guerin, Caroline Hauw-Berlemont, Michaela Fontenay, Aurélien Philippe, Pascale Gaussem, Jean-Luc Diehl, Richard Chocron, Olivier Sanchez, Lina Khider, Elise Sourdeau, Georges Jourdi, Nicolas Gendron, Guillaume Goudot, Tali-Anne Szwebel, Nadia Rivet, Julie Brichet
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Cancer Research
Letter
Physiology
Angiogenesis
Clinical Biochemistry
Kaplan-Meier Estimate
Gastroenterology
Severity of Illness Index
law.invention
0302 clinical medicine
law
Medicine
Hospital Mortality
Endothelial dysfunction
biology
Respiratory disease
Middle Aged
Intensive care unit
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
Adult
medicine.medical_specialty
Paris
Multimers
Microthrombosis
03 medical and health sciences
Von Willebrand factor
Internal medicine
von Willebrand Factor
Humans
Mortality
Pandemics
Endotheliitis
Aged
Proportional Hazards Models
Original Paper
business.industry
Proportional hazards model
SARS-CoV-2
Endothelial activation
COVID-19
Thrombosis
medicine.disease
Molecular Weight
030104 developmental biology
Cross-Sectional Studies
biology.protein
Endothelium
Vascular
Protein Multimerization
business
Biomarkers
Zdroj: Angiogenesis
ISSN: 1573-7209
Popis: Background Coronavirus disease 2019 (COVID-19) is a respiratory disease associated with endotheliitis and microthrombosis. Objectives To correlate endothelial dysfunction to in-hospital mortality in a bi-centric cohort of COVID-19 adult patients. Methods Consecutive ambulatory and hospitalized patients with laboratory-confirmed COVID-19 were enrolled. A panel of endothelial biomarkers and von Willebrand factor (VWF) multimers were measured in each patient ≤ 48 h following admission. Results Study enrolled 208 COVID-19 patients of whom 23 were mild outpatients and 189 patients hospitalized after admission. Most of endothelial biomarkers tested were found increased in the 89 critical patients transferred to intensive care unit. However, only von Willebrand factor antigen (VWF:Ag) scaled according to clinical severity, with levels significantly higher in critical patients (median 507%, IQR 428–596) compared to non-critical patients (288%, 230–350, p
Databáze: OpenAIRE
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