Autor: |
Florence Desvard, Françoise Levasseur, Sébastien Bertil, Tristan Mirault, David M. Smadja, Olivier Bory, Benjamin Planquette, Nicolas Peron, Benjamin Terrier, Jérôme Duchemin, Cherifa Cheurfa, Christophe Peronino, Agathe Beauvais, Frédéric Pène, Bertrand Hermann, Coralie L. Guerin, Caroline Hauw-Berlemont, Michaela Fontenay, Aurélien Philippe, Pascale Gaussem, Jean-Luc Diehl, Richard Chocron, Olivier Sanchez, Lina Khider, Elise Sourdeau, Georges Jourdi, Nicolas Gendron, Guillaume Goudot, Tali-Anne Szwebel, Nadia Rivet, Julie Brichet |
Rok vydání: |
2020 |
Předmět: |
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Zdroj: |
Angiogenesis |
ISSN: |
1573-7209 |
Popis: |
Background Coronavirus disease 2019 (COVID-19) is a respiratory disease associated with endotheliitis and microthrombosis. Objectives To correlate endothelial dysfunction to in-hospital mortality in a bi-centric cohort of COVID-19 adult patients. Methods Consecutive ambulatory and hospitalized patients with laboratory-confirmed COVID-19 were enrolled. A panel of endothelial biomarkers and von Willebrand factor (VWF) multimers were measured in each patient ≤ 48 h following admission. Results Study enrolled 208 COVID-19 patients of whom 23 were mild outpatients and 189 patients hospitalized after admission. Most of endothelial biomarkers tested were found increased in the 89 critical patients transferred to intensive care unit. However, only von Willebrand factor antigen (VWF:Ag) scaled according to clinical severity, with levels significantly higher in critical patients (median 507%, IQR 428–596) compared to non-critical patients (288%, 230–350, p |
Databáze: |
OpenAIRE |
Externí odkaz: |
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