Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients
| Autor: | Elle K.J. Risse, Tom G. Sutedja, Arifa Pasic, Pieter E. Postmus, Anton Vonk-Noordegraaf |
|---|---|
| Přispěvatelé: | VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Cancer Research Pathology medicine.medical_specialty Lung Neoplasms Databases Factual Population Sensitivity and Specificity Fluorescence Lesion Cohort Studies Bronchoscopy Predictive Value of Tests Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans education Lung cancer Aged Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Cancer Middle Aged medicine.disease respiratory tract diseases Cell Transformation Neoplastic Oncology Carcinoma Squamous Cell Population study Female medicine.symptom business Precancerous Conditions Lung cancer screening Follow-Up Studies |
| Zdroj: | Pasic, A, Vonk Noordegraaf, A, Risse, E K J, Postmus, P E & Sutedja, G 2003, ' Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients. ', Lung Cancer, vol. 41, no. 3, pp. 295-301 . https://doi.org/10.1016/S0169-5002(03)00191-0 Lung Cancer, 41(3), 295-301. Elsevier Ireland Ltd |
| ISSN: | 0169-5002 |
| Popis: | Autofluorescence bronchoscopy (AFB) has been shown to be sensitive to detect preneoplastic lesions in central airways. Apart from bronchial mucosa thickness, tissue autofluorescence is also related to the biochemical properties of the target cells. Genetic studies have shown molecular abnormalities to be present in histologically normal mucosal specimens. Forty-six high-risk individuals, free of micro-invasive cancer at the initiation of the study, were included in this analysis and have been subjected to repeat bronchoscopic examinations every 4-6 months. They had previous curatively treated lung cancer (n=18), ENT tumor (n=11) or were at risk to acquire lung cancer primaries (n=17). Baseline AFB is scored for each suspicious lesion, thus the total score represents the number of AFB suspicious lesions present in each individual at risk. Baseline AFB score was correlated to outcome, i.e. the development of squamous-cell cancer (SCC) in each individual. So far, 11/46 (24%) of the individuals acquired SCC. Follow up has been 12-80 months. All five individuals with >/=3 lesions (100%, 12-36 months), five of the ten (50%, 12-48 months) individuals who had two lesions and one among the 12 (8%, 36 months) individuals with one suspicious AFB lesion, developed SCC. Up till now (12-80 months), the remaining 19 individuals without any suspicious AFB lesion have not acquired SCC. The average AFB score for the group of individuals which developed SCC was significantly different (P |
| Databáze: | OpenAIRE |
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