Synthesis, characterization and DNA interactions of [Pt3(TPymT)Cl3], the trinuclear platinum(II) complex of the TPymT ligand
| Autor: | Tiziano Marzo, Nancy Di Pasquale, Matteo Stefanini, Alessandro Feis, Tarita Biver, Luigi Messori, Chiara Gabbiani, Damiano Cirri, Lorenzo Ciofi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Ligand Dna interaction chemistry.chemical_element Anticancer drug DNA 010402 general chemistry Mass spectrometry 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences Characterization (materials science) Coordination complex Coordination chemistry TPymT Inorganic Chemistry chemistry.chemical_compound Crystallography chemistry Platinum |
| Popis: | The triplatinum complex of the 2,4,6-Tris(2-pyrimidyl)-1,3,5-triazine ligand, Pt 3 TPymT hereafter, has been prepared and characterized for the first time. NMR studies point out that the three platinum(II) centers possess an identical coordination environment. The interactions of Pt 3 TPymT with DNA were explored in comparison to the free ligand. Specifically, fluorescence, mass spectrometry, viscometry and melting measurements were carried out. In contrast to expectations, the obtained data reveal that no intercalative binding takes place; we propose that binding of Pt 3 TPymT to DNA mainly occurs through external/groove binding. |
| Databáze: | OpenAIRE |
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