Refractory status epilepticus and autoimmune encephalitis with GABAAR and GAD65 antibodies: A case report
| Autor: | Karim Mourabit Amari, Martin Savard, Maude-Marie Gagnon |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_treatment Clinical Neurology Status epilepticus Hashimoto Disease 03 medical and health sciences Epilepsy 0302 clinical medicine Status Epilepticus Recurrence Limbic Encephalitis medicine Humans Autoantibodies Autoimmune encephalitis biology business.industry Glutamate Decarboxylase Autoantibody Electroencephalography General Medicine Immunotherapy medicine.disease Receptors GABA-A Dysosmia 030104 developmental biology nervous system Neurology Immunology biology.protein Encephalitis Female Neurology (clinical) medicine.symptom Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Seizure. 37 |
| ISSN: | 1532-2688 |
| Popis: | Purpose Autoimmune encephalitis is an inflammatory disorder of the brain that may be associated with different neuronal antibodies. Recently, an increasing number of valuable autoantibodies have been identified, including GABA A R antibodies, which appear to be associated with a severe form of encephalitis with refractory status epilepticus. We report here on a patient with encephalitis associated with GAD65 and GABA A R antibodies, an entity that remains an understudied topic, with an unanticipated clinical presentation and we describe the longitudinal follow-up. Methods We report a case of encephalitis associated with GAD65 and GABA A R antibodies; we describe clinical and paraclinical features and the longitudinal follow-up. Results Our case presented with dysgueusia, dysosmia and episodes of hyperventilation that evolved into a refractory status epilepticus. Multiple anticonvulsant drugs were required. An aggressive immunotherapy was associated with a relative favorable outcome, in regard of epilepsy and cognitive functions. However, a relapse occurred and a full recovery was not observed at the last follow-up visit. There was no correlation between GAD65 antibodies titers and disease activity. Conclusion Autoimmune encephalitis associated with GABA A R and GAD65 antibodies might be a severe and refractory disease. The appropriate treatment is currently unknown for those patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect