Clinicopathologic correlation of C1q nephropathy in children
| Autor: | Akihisa Mitsudome, Noboru Tsuru, Kazuhiko Niimi, Yoshitsugu Kaku, Yuko Fukuma, Ken Hatae, Yasuhiro Kiyoshi, Satoshi Hisano, Hiroshi Iwasaki, Yoshie Segawa |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Nephrotic Syndrome Adolescent Asymptomatic Focal segmental glomerulosclerosis Biopsy Medicine Humans Minimal change disease Child medicine.diagnostic_test business.industry Glomerulosclerosis Focal Segmental Complement C1q Nephrosis Lipoid medicine.disease Surgery Nephrology Child Preschool Prednisolone Mesangial proliferative glomerulonephritis Female medicine.symptom business Nephrotic syndrome medicine.drug Kidney disease |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 47(3) |
| ISSN: | 1523-6838 |
| Popis: | Background: Clinicopathologic correlation of C1q nephropathy is clarified poorly. The aim of our study is to clarify clinicopathologic correlation in childhood C1q nephropathy. Methods: Thirty children aged 3 to 15 years who met criteria proposed by Jennette and Hipp were enrolled in this study. Results: According to their presentation at onset, children were divided into 2 groups: the asymptomatic urinary abnormalities (asymptomatic) group (n = 18) and the nephrotic syndrome (NS) group (n = 12). Light microscopy showed minimal change disease (MCD) in 22 children (73%), mesangial proliferative glomerulonephritis in 6 children (20%), and focal segmental glomerulosclerosis (FSGS) in 2 children (7%). Four children in the asymptomatic group and all children in the NS group were administered prednisolone and/or cyclosporine. Normal urinalysis results were found in 8 children in the asymptomatic group and 3 children in the NS group during the follow-up period of 3 to 15 years. Eight children in the NS group were frequent relapsers at the latest follow-up. Two children with FSGS (1 child, asymptomatic group; 1 child, NS group) received dialysis 10 and 15 years after the diagnosis. There were no differences in histological findings and clinical outcomes between the 2 groups. Four children with MCD in the NS group underwent a second biopsy. C1q deposits disappeared in 2 children, and 1 of these 2 children showed FSGS. Conclusion: Childhood C1q nephropathy is found in a wide clinical spectrum. Some children showed disappearance of C1q deposits through the follow-up period. A large number of children with C1q nephropathy showed MCD. However, FSGS may develop in some children on repeated biopsy. Therefore, long-term follow-up is needed in children with C1q nephropathy. |
| Databáze: | OpenAIRE |
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