Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
| Autor: | Robert S. Liwski, S. Marc Breedlove, David A. Puts, Anna Greenshields, Adam C. Davis, Riley Desmarais, Ellen E. Quillen, Steven Arnocky, Carolyn R. Hodges-Simeon, Rodrigo A. Cárdenas |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Heterozygote Adolescent Evolution Science Physiology 030209 endocrinology & metabolism Human Males Human leukocyte antigen Lower risk Major histocompatibility complex Article Major Histocompatibility Complex Loss of heterozygosity Young Adult 03 medical and health sciences 0302 clinical medicine Humans Sexual maturity Genetic Predisposition to Disease Alleles Disease Resistance 030304 developmental biology 0303 health sciences Multidisciplinary biology Evolutionary theory Puberty Infectious disease (medical specialty) biology.protein Medicine Evolutionary developmental biology Disease Susceptibility Self Report Immunocompetence |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-99334-5 |
| Popis: | Individual variation in the age of pubertal onset is linked to physical and mental health, yet the factors underlying this variation are poorly understood. Life history theory predicts that individuals at higher risk of mortality due to extrinsic causes such as infectious disease should sexually mature and reproduce earlier, whereas those at lower risk can delay puberty and continue to invest resources in somatic growth. We examined relationships between a genetic predictor of infectious disease resistance, heterozygosity of the major histocompatibility complex (MHC), referred to as the human leukocyte antigen (HLA) gene in humans, and self-reported pubertal timing. In a combined sample of men from Canada (n = 137) and the United States (n = 43), MHC heterozygosity predicted later self-reported pubertal development. These findings suggest a genetic trade-off between immunocompetence and sexual maturation in human males. |
| Databáze: | OpenAIRE |
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