Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses
| Autor: | Wen-Fu Tang, Jesse K. Fletcher, Tony Y. Hu, Christopher J. Lyon, Mei-Hua Wan, Qian Hu |
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| Rok vydání: | 2021 |
| Předmět: |
ALI
acute lung injury Macrophage medicine.medical_treatment Review DSS dextran sodium sulphate Targeted therapy HUCMSCs human umbilical cord mesenchymal stem cells 0302 clinical medicine General Pharmacology Toxicology and Pharmaceutics ICAM-1 intercellular adhesion molecule 1 TNF tumor necrosis factor 0303 health sciences Stem cell IBD inflammatory bowel disease Chemistry EVs extracellular vesicles Extracellular vesicle Extracellular vesicles iNOS inducible nitrogen oxide synthase Phenotype MSCs mesenchymal stromal cells Cell biology Inflammatory disease 030220 oncology & carcinogenesis Interaction loop CLP cecal ligation and puncture ADSCs adipose-derived stem cells AMs alveolar macrophages TECs tubular epithelial cells Drug carrier IL-1β interleukin-1β PMFA 5 7 30 40 50-pentamethoxyflavanone RM1-950 AKI acute kidney injury SIRPα signal regulatory protein α Sepsis 03 medical and health sciences KLF4 krüppel-like factor 4 TRAIL tumor necrosis factor-related apoptosis-inducing ligand BMSCs bone marrow stromal cells medicine MHC major histocompatibility complex PEG polyethylene glycol 030304 developmental biology HSPA12B heat shock protein A12B MVs microvesicles Tissue injury medicine.disease PPARγ peroxisome proliferator-activated receptor γ LPS lipopolysaccharides KCs Kupffer cells Therapeutics. Pharmacology |
| Zdroj: | Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1493-1512 (2021) |
| ISSN: | 2211-3835 |
| DOI: | 10.1016/j.apsb.2020.12.014 |
| Popis: | Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation, injury, and repair processes. Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles (EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury, and vice versa. This review discusses the roles of such EVs in regulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions, and the potential applications, advantage and concerns for using EV-based therapeutic approaches to treat such conditions, including their potential role of drug carriers for the treatment of infectious diseases. Graphical abstract Macrophages and tissue cells can communicate via extracellular vehicles (EVs) to regulate tissue injury and tissue repair. Targeting these EV interactions mechanisms may lead to new therapeutic strategies for acute and chronic inflammatory conditions.Image 1 |
| Databáze: | OpenAIRE |
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