Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058

Autor:	Ilya V. Likhachev, Robert Karisch, Roni D. Gordon, Benjamin G. Neel, Max Ruzanov, Andres Lin, Evgeniy V. Brazhnikov, Kevin P. Battaile, Vladimir Romanov, Nikolay K. Balabaev, Nickolay Y. Chirgadze, Yuri N. Chirgadze, Robert Lam, Emil F. Pai
Rok vydání:	2021
Předmět:	chemistry.chemical_classification animal structures Binding Sites Chemistry Allosteric regulation General Medicine Protein tyrosine phosphatase Molecular Dynamics Simulation environment and public health enzymes and coenzymes (carbohydrates) Hydrolysis Cytosol Enzyme Biochemistry Diabetes Mellitus Type 2 Structural Biology Humans Obesity Enzyme Inhibitors Phosphorylated proteins Molecular Biology Signal Transduction
Zdroj:	Journal of biomolecular structuredynamics. 40(24)
ISSN:	1538-0254
Popis:	Protein tyrosine phosphatases constitute a family of cytosolic and receptor-like signal transducing enzymes that catalyze the hydrolysis of phospho-tyrosine residues of phosphorylated proteins. PTP1B, encoded by
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e71409809f02b116f991302bae9b48 https://pubmed.ncbi.nlm.nih.gov/34705594 Zobrazit plný text záznamu