The domineering non-autonomy of frizzled and Van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling
| Autor: | Jeannette Charlton, Job Taylor, Paul N. Adler |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Frizzled
Embryology animal structures Polarity (physics) Genes Insect Biology Models Biological Receptors G-Protein-Coupled Cell autonomous Planar cell polarity Animals Drosophila Proteins Wings Animal Alleles Body Patterning Genetics Wing Domineering Mosaicism Pupa Membrane Proteins LIM Domain Proteins Frizzled Receptors DNA-Binding Proteins Mutation Drosophila Signal Transduction Developmental Biology |
| Zdroj: | Mechanisms of Development. 96(2):197-207 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(00)00392-0 |
| Popis: | The frizzled (fz) gene is required for the development of distally pointing hairs on the Drosophila wing. It has been suggested that fz is needed for the propagation of a signal along the proximal distal axis of the wing. The directional domineering non-autonomy of fz clones could be a consequence of a failure in the propagation of this signal. We have tested this hypothesis in two ways. In one set of experiments we used the domineering non-autonomy of fz and Vang Gogh (Vang) clones to assess the direction of planar polarity signaling in the wing. prickle (pk) mutations alter wing hair polarity in a cell autonomous way, so pk cannot be altering a global polarity signal. However, we found that pk mutations altered the direction of the domineering non-autonomy of fz and Vang clones, arguing that this domineering non-autonomy is not due to an alteration in a global signal. In a second series of experiments we ablated cells in the pupal wing. We found that a lack of cells that could be propagating a long-range signal did not alter hair polarity. We suggest that fz and Vang clones result in altered levels of a locally acting signal and the domineering non-autonomy results from wild-type cells responding to this abnormal signal. |
| Databáze: | OpenAIRE |
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