Fungal-derived carboxymethyl chitosan blended with polyvinyl alcohol as membranes for wound dressings
| Autor: | Kummara Madhusudana Rao, Maduru Suneetha, Kuncham Sudhakar, So Yeon Won, Sung Soo Han |
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| Rok vydání: | 2021 |
| Předmět: |
Keratinocytes
Vinyl alcohol Biocompatibility Cell Survival Biocompatible Materials Microbial Sensitivity Tests Biochemistry Polyvinyl alcohol Cell Line chemistry.chemical_compound Crystallinity X-Ray Diffraction Structural Biology Tensile Strength Spectroscopy Fourier Transform Infrared medicine Animals Molecular Biology Cell Shape Skin Chitosan Wound Healing Sheep integumentary system Bacteria Water Membranes Artificial General Medicine Fibroblasts medicine.disease Bandages Hemolysis Anti-Bacterial Agents Membrane chemistry Chemical engineering Polyvinyl Alcohol Wettability Swelling medicine.symptom Antibacterial activity Agaricales |
| Zdroj: | International journal of biological macromolecules. 190 |
| ISSN: | 1879-0003 |
| Popis: | Multifunctional blend membranes composed of poly (vinyl alcohol) (PVA) and fungal mushroom-derived carboxymethyl chitosan (F-CMCS) were produced using a simple solution casting technique for wound dressing applications. The structural interactions between PVA and F-CMCS were confirmed by Fourier infrared spectroscopy. The crystallinity of the membranes was examined by X-ray diffraction. Field emission scanning electron microscopy confirmed the homogeneity and coarser texture with a porous-like network in the internal structure of the membranes. The hydrophilicity, swelling, and degradation of the fabricated membranes were examined according to the F-CMCS content. The PVA/F-CMCS membrane displayed potential antibacterial activity against Escherichia coli (gram-negative) and Staphylococcus (gram-positive) bacteria. An in vitro cell study of skin fibroblasts and keratinocytes on the PVA/F-CMCS membranes confirmed the biocompatibility. The hemolysis assay demonstrated the hemocompatibility of the developed membranes. The antibacterial, biocompatibility, and good hemolysis in the PVA membrane were influenced by the F-CMCS composition ratio up to 40%. The all-inclusive properties of the PVA/F-CMCS membranes highlight its potential use in wound dressing applications. |
| Databáze: | OpenAIRE |
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